BRAF mutation in papillary carcinoma of the thyroid

BRAF mutation in papillary carcinoma of the thyroid: Clinical implication and cytomorphology correlation n Fine needle aspiration is widely utilized for evaluation of patients with thyroid nodules. A recent important genetic finding in papillary thyroid carcinoma is the oncogenic T 1799 A transversion mutation of the gene for the B-type Raf kinase (BRAF). In this study, we analyzed the relationship between BRAF mutation, cytomorphology of papillary thyroid carcinoma, and their clinical features. Among 53 papillary thyroid carcinoma studied, 68 % had mutated BRAF. Our results showed that activating mutation of BRAF gene correlated significantly with nuclear grooves (p = 0. 0026), chewing gum colloid (p = 0. 0154), and metaplastic cell (p = 0. 0014). BRAF mutation were associated with old age, extrathyroidal invasion, and advanced tumor stage at presentation.