BPH Prostate cancer Hanjong Park Ph D RN

BPH Prostate cancer Hanjong Park, Ph. D, RN

Benign Prostatic Hyperplasia(BPH), 양성전립선 비대증 • “Benign enlargement of prostate gland • Most common urologic problem in male adults • 50% of all men in their lifetime will develop BPH • BPH is a risk factor for developing prostate cancer” (Lewis et al. , 2014, p. 1307) 2 (Lewis et al. , 2014, p. 1308)

BPH: Etiology • Hormonal changes associated with aging process • dihydroxytestosterone (DHT) (the principal intraprostatic androgen, 전립선내 초기 안드로겐) ↑ in the prostate cells • increased proportion of estrogen (as compared to testosterone) in the blood • Aging • Obesity (waist circumference ↑) • Smoking • Diabetes • Lack of physical activity • Alcohol consumption ↑ • Erectile dysfunction • May have family history of BPH(first-degree relatives) 김금순 외(2012), Lewis et al. (2014) 3

BPH : Clinical manifestations (similar to neurogenic bladder) Minimal early symptoms urethral obstruction Irritative symptoms associated with inflammation: Nocturia, urinary frequency, urgency, dysuria, bladder pain, incontinence Obstructive symptoms by prostate enlargement & urinary retention: Weak urinary stream, difficulty in initiating voiding, intermittency, dribbling at the end of urination 김금순 외(2012), Lewis et al. (2014) 4

BPH : diagnostic studies • • • History Digital rectal examination(DRE, 지두직장검진법): size, symmetry, firm/smooth Urinalysis with culture: WBCs, microscopic hematuria Prostate-specific antigen(PSA, 전립선특이항원): slight elevation, to rule out prostate cancer, normal PSA < 4. 0 ng/m. L Serum creatinine Postvoid residual Transrectal ultrasound(TRUS, 경직장초음파촬영술) scan: accurate check of prostate size, to rule out prostate cancer, + biopsies(maybe) Uroflowmetry(요속측정법): extent of urethral blockage, checking type of needed tx Cystoscopy 김금순 외(2012), Lewis et al. (2014) 6

BPH : Collaborative care 1 Minimally invasive(최소한의 침습적 시술) • Transurethral Microwave Thermotherapy(TUMT, 경요도 극초단파 열요법) • Transurethral Needle Ablation(TUNA, 경요도 침 절제술) • Transurethral Electrovaporization of Prostate(TUVP, 경요도 전립선 전기기화법) • Intraprostatic Urethral Stents(전립선내 요도 스텐트) • Laser Prostatectomy(레이저 전립선 절제술) Invasive surgery(침습적 수술) • Transurethral Resection of Prostate(TURP, 경요도 전립선 절제술) • Transurethral incision of prostate(TUIP, 경요도 전립선 절개술) • Open Prostatectomy(개방적 전립선 절제술) 김금순 외(2012), Lewis et al. (2014) 7

BPH : Collaborative care 2 Drug therapy • 5α-Reductase inhibitors(5α환원효소 억제제: 전립선비대 억제, 효과-3 -6 months): finasteride [Proscar]- when scores of AUA symptom index > 20 -35, dutasteride[Avodart] • Α-Adrenergic receptor blockers(α교감신경수용체 차단제: 전립선평활근이완, 효과-2 -3 weeks): silodosin [Rapaflo], alfuzosin[Uroxatral], doxazosin [Cardura], prazosin [Minipress], terazosin[Hytrin], tamsulosin [Flomax]) • 5α-Reductase inhibitors+ α-Adrenergic receptor blockers: dutasteride + tamsulosin [Jalyn] • Erectogenic drugs: tadalafil [Cialis] 8 김금순 외(2012), Lewis et al. (2014)

Prostate cancer, 전립선암 • “malignant tumor of the prostate gland • Most common cancer among men > 65 years old (1/6 men) • Younger men: more aggressive type of cancer” (Lewis et al. , 2014, p. 1315) 10

Prostate cancer : Etiology • androgen-dependent adenocarcinoma • slow growing(usually) • 3 routes: direct extension, lymph system, blood stream(pelvic bones, femur head, lower lumbar spine, liver, lungs) 11 김금순 외(2012), Lewis et al. (2014)

Prostate cancer : Etiology • Risk factors • Known: Age, ethnicity(African American>white>Asian A. ), family history • Unknown: Smoking , Vitamin D, E (maybe) • BPH • Obesity • Diet: High fat dairy, high in red and processed meat, Low intake of vegetables, fruits • Genetic link: Hereditary breast and ovarian cancer(HBOC) syndrome, Mutation in BRCA 1 and BRCA 2 12 김금순 외(2012), Lewis et al. (2014)

Prostate cancer : Clinical manifestations (similar to BPH) Usually asymptomatic in the early stage urethral obstruction BPH like symptoms: dysuria, hesitancy, dribbling, frequency, urgency, hematuria, nocturia, retention, interruption of urinary stream, inability to urinate Symptoms associated with metastasis: Severe pain when bone metastasis(common site) pain in the back and legs(요통, 좌골신경통) due to spinal cord compression & bone destruction 13 김금순 외(2012), Lewis et al. (2014)

Classification for staging Prosate cancer Lewis et al. (2014, p. 1317) Stage I to IV (A to D) 14 (2015, November 1). New Hope for Prostate Cancer Detection. Retrieved from http: //www. tiofsw. com/new-hope-for-prostate-cancer-detection/

Prostate cancer : diagnostic studies • History • Digital rectal examination(DRE, 지두직장검진법): 비대칭적, 돌처럼 단단함 • Prostate-specific antigen(PSA, 전립선특이항원): for early detection & monitoring treatment effects, normal PSA < 4. 0 ng/m. L • Prostatic acid phosphatase(PAP, 혈청 산성인산효소): normal < 2. 5 ng/m. L • Serum alkaline phosphatase for advanced prostate cancer(e. g, bone metastasis) • Transrectal ultrasound(TRUS, 경직장초음파촬영술) scan with biopsy: biopsy confirms the diagnosis • Bone scan checking spread of prostate cancer • CT, MRI using endorectal probe 15 김금순 외(2012), Lewis et al. (2014)

Prostate cancer : Collaborative care 1 Watchful waiting(보존적 요법) • DRE & PSA follow up • 기대수명이 10년 이하 • 유의한 공존질병 있을시 • 낮은 등급, 병기의 종양시 Surgery therapy (침습적 수술) • Radical prostatectomy(근치적 전립선 절제술) • Nerve-sparing procedure(신경보존술) • Cryosurgery(전립선 동결수술) 16 김금순 외(2012), Lewis et al. (2014)

Prostate cancer : Collaborative care 2 Drug therapy Therapy Mechanism of action Side effects LH-RH agonists(촉진제) leuprolide (Lupron, Lupron Depot, Eligard, Viadur) goserelin (Zoladex) triptorelin (Trelstar) buserelin (Suprefact) LH-RH Antagonist(길항제) degarelix Reduce secretion of LH and FSH Decrease testosterone production Hot flahes, gynecomastia, decreased libido, erectile dysfunction Depression & mood change SC or IM injection Blocks LH receptors Immediate testosterone suppression SC injection Pain, redness, swelling at injection site, elevated liver enzymes LH-RH(luteinzing hormone releasing hormone)황체형성 호르몬 분비호르몬 18 김금순 외(2012), Lewis et al. (2014, table 55 -7 , p. 1319)

Prostate cancer : Collaborative care 2 Drug therapy Therapy Mechanism of action Side effects Androgen receptor blockers Bicalutamide(Casodex) Flutamide(Eulexin) Nilutamide(Nilandron) Enzalutamide(Xtandi) Block action of testosterone by competing with receptor sites Loss of libido, erectile dysfunction, hot flashes Breast pain and gynecomastia may occur Estrogen Diethylstibestrol(Des) LH 분비 억제, 테스토스 테론 생산 감소, 순환 테 스토스테론 차단 Oral medication 김금순 외(2012), Lewis et al. (2014, table 55 -7 , p. 1319) 19

Prostate cancer : Collaborative care 2 Drug therapy • 항암화학요법: 호르몬 불응성 전립선암(hormone-refractory prostatic cancer, HRPC) 환자에게 제한적 적용 • docetaxel(Taxotere), cabazitaxel (Jevtana), paclitaxel (Abraxane), mitoxantrone (Novantrone), vinblastine (Velban), cyclophosphamide (Cytoxan), and estramustine (Emcyt). • vaccine (sipuleucel-T [Provenge] which stimulates the patient’s system against the cancer and may prolong survival. 20 김금순 외(2012), Lewis et al. (2014)

References • 김금순 외(2012). 성인간호학 II, 7판. 수문사 • Lewis, Sharon L. ; Dirksen, Shannon Ruff; Heitkemper, Margaret M. ; Bucher, Linda (2014). Medical-Surgical Nursing: Assessment and Management of Clinical Problems, Single Volume. Elsevier Health Sciences. Kindle Edition. 22