Bone marrow mesenchymal stromal cells induce nitric oxide

Bone marrow mesenchymal stromal cells induce nitric oxide synthase-dependent differentiation of CD 11 b+ cells that expedite hematopoietic recovery by Cristina Trento, Ilaria Marigo, Alice Pievani, Antonio Galleu, Luigi Dolcetti, Chun. Yin Wang, Marta Serafini, Vincenzo Bronte, and Francesco Dazzi haematol Volume 102(5): 818 -825 April 30, 2017 © 2017 by Ferrata Storti Foundation

Mesenchymal stromal cells induce the differentiation of bone marrow mononuclear cells into myeloid cells. Cristina Trento et al. Haematologica 2017; 102: 818 -825 © 2017 by Ferrata Storti Foundation

Mesenchymal stromal cell-induced CD 11 b+ cells consist of a large proportion of M 0 macrophages. Cristina Trento et al. Haematologica 2017; 102: 818 -825 © 2017 by Ferrata Storti Foundation

Mesenchymal stromal cell-induced CD 11 b+ differentiation targets committed myeloid progenitors but not hematopoietic stem cells. Cristina Trento et al. Haematologica 2017; 102: 818 -825 © 2017 by Ferrata Storti Foundation

Mesenchymal stromal cell-induced myeloid cell formation is Nos 2 -dependent. Cristina Trento et al. Haematologica 2017; 102: 818 -825 © 2017 by Ferrata Storti Foundation

Adoptive transfer of mesenchymal stromal cells increases macrophage formation during hematopoietic reconstitution. Cristina Trento et al. Haematologica 2017; 102: 818 -825 © 2017 by Ferrata Storti Foundation

Adoptive transfer of mesenchymal stromal cell-induced CD 11 b+ cells accelerates engraftment. Cristina Trento et al. Haematologica 2017; 102: 818 -825 © 2017 by Ferrata Storti Foundation

Human mesenchymal stromal cells induce the differentiation of human bone marrow mononuclear cells into myeloid cells. Cristina Trento et al. Haematologica 2017; 102: 818 -825 © 2017 by Ferrata Storti Foundation