Body Fluid Compartments Specific learning objectives At the
Body Fluid Compartments
Specific learning objectives At the end of the class You must know. . § Give the normal values of total body water as % of body weight in different age group in male and female. § Give the % distribution of body water in different body fluide compartments. § Name different body fluide compartments. § Differentiate the total fluide present in the compartment. § Explain the measurement of body fluide volume of different compartments.
Body composition • In average young adult male: Body composition % of body weight Protein, & related substances 18% Fat 15% Mineral 7% Water 60%
TOTAL BODY WATER(TBW) • 60% OF THE BODY WEIGHT IN ADULT MALE • 50% OF THE BODY WEITH IN ADULT FEMALE
FLUID COMPARTMENTS EXTRA CELLUAR FLUID PLASMA INTRA CELLULAR FLUID INTERSTITIAL FLUID CSF Intra ocular Pleural Peritoneal Synovial Digestive Secretions TRANSCELLULAR FLUID
Body Fluids Water content in body is divided into 2 compartments: 1. Extracellular fluid (ECF): (internal environment or the milieu intérieur) Ø Fluid outside the cells. Ø ECF=14 liters Ø 20% of body weight Ø Interstitial fluid between cell is 80% of ECF. Ø Plasma in blood is 20% of ECF Ø Also includes lymph, cerebrospinal fluid, synovial fluid, aqueous humor, vitreous body, endolymph, peri lymph, pleural, pericardial, and peritoneal fluids
2. Intracellular fluid (ICF): Ø Fluid inside the cells. Ø ICF=28 liters. Ø 40% 0 f body weight.
Total Body Water ECF Blood ICF Interstitial ICF BLOOD ICF
VOLUME OF BODY FLUIDS IN 70 kg MAN TOTAL VOLUME 42 L INTRA CELLUAR FLUID 28 L(ROUGHLY 2/3 OF TBW) EXTRA CELLULAR FLUID 14 L(ROUGHLY 1/3 OF TBW)
CATIONS (mmol/L of H 2 o) Na Plasma Interstitial Intracellular COMPOSITION FLUIDS 142 OF BODY 139 14 K 4. 2 4. 0 140 Ca 1. 3 1. 2 0 Mg 0. 8 0. 7 20 Cl 108 4. 0 HCO 3 24. 0 28. 3 10 Protein 1. 2 0. 2 4. 0 HPO 4 2. 0 11 ANIONS (mmol/L of H 2 o)
MEASUREMENT OF BODY FLUID COMPARTMENT INTERSTITIAL FLUID ECF – Plasma Volume INTRACELLULAR FLUID TBW – ECF
SUMMARY
REFERENCES 1. Comprehensive Textbook of Medical physiology (Vol 1 first edition)- G K Pal 2. Text book of medical physiology (Vol 2 6 th edition)- A K Jain. 3. Essentials of medical physiology (6 th edition)- K Sembulingam and prema. Sembulingam
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