Blood Type and Multiple Alleles What is blood

Blood Type and Multiple Alleles

What is blood type? • Inherited Trait • Phenotypic expression: antigenic surface proteins (markers) • ABO possibilities (multiple alleles each person inherits 2) • Example: AB+ means surface antigens for A, B and Rh markers • O- no surface markers.

What is RH (Rhesus)? • inherited protein surface of red blood cells. • Rh positive w/ protein • No Protein = Rh negative Think with partner • RH negative blood makes RH antibodies • Can RH positive receive RH negative blood? Vice versa?

What type of inheritance is blood type? Autosomal inheritance (non-sex chromo) Chromosome 9 Remember autosomes are homologous (similar size and corresponding type of genes)

All Genes Have a Set Location Gene Loci

Reminder!

Antigens on Red Blood Cells Type Antigens Type AB+ AB- A+ A- B+ B- O+ O- Antigens

Antibodies – Opposite of Antigen Type Antigens Antibody Type AB+ AB- A+ A- B+ B- O+ O- Antigens Antibody

Who Can Receive or Donate Blood! Type AB+ A+ B+ O+ ABAB- O- Give to Get From Why? No Antibodies made Antibodies B Antibodies A A, B Antibodies

What patterns do you notice for blood type? Title: Patterns and list 2 -4

What are inheritance possibilities?

AB is Codominance (both dominant) What type of inheritance is Blood Type O is complete dominance- recessive to type A or type B Thus, Blood type O needs two OO alleles Type A can be genotype AA or AO B can be genotype BB or BO

Do the following practice problems 1) Cross type O blood type (O is recessive) with homozygous A (AA). List genotypic and phenotypic ratios. 2) Cross AB blood type with heterozygous B. List genotypic and phenotypic ratios. 3) Cross a heterozygous A with heterozygous B.

Number 1

Number 2

Number 3

Who can save Fluffy? • Test Muffy, Scruffy and Tuffy’s blood type. • use information from notes and blood type info to determine the best match! • The blood agglutinates if antibodies are present. Use your notes to help determine the blood type.