Biophysics and Computational Biology National Central University Computational
Biophysics and Computational Biology 生物物理與計算生物 National Central University 國立中央大學物理系 李弘謙 Computational Biology Laboratory 計算生物實驗室 CBL@NCU 2002 January 24
There are 24 human Human has 23 chromosomes There are 24 human chromosomes 人類有 二十四種 染色體 CBL@NCU
Millions of sequences Millions of base pairs of DNA 排序完成的基因序列近年以爆炸性成長 (As of 2002 January 13) CBL@NCU
已完成排序的大基因體 1995 -2002 – About 35 bacterial genomes; 細菌 已完成排序的大基因體 0. 5 -5 Mb; hundreds to 2000 genes 1996 April – Yeast (Saccharomyces cerevisiae) 12 Mb, 5, 500 genes 酵母 1998 Dec. -Worm (Caenorhabditis elegans) 97 Mb, 19, 000 genes 線蟲 2000 March - Fly (Drosophila melanogaster) 137 Mb, 13, 500 genes 果蠅 2000 Dec. - Mustard (Arabidopsis thaliana) 125 Mb, 25, 498 genes 芥末 2000 June – Human (Homo sapiens) 1 st rough draft 2001 Feb 15/16 – Human, “working draft” 人類 3000 Mb, 35, 000~40, 000 genes CBL@NCU
Life Science in silico CBL@NCU 在電腦中研究生命科學 用電腦研究生命科學 [biology] 生物 + [computer-science] 電腦 + [math & physics] 數理 “It is much easier to teach biology to people from a math, physics or computer-science background than to teach a biologist how to code well. ” - Nature, February 15, 2001, p 963
最早期的細胞演化 真細菌 真核生物 古細菌 10億年前 20億年前 30億年前 40億年前 WF Doolittle, Proc. Natl. Acad. Sci. USA, Vol. 94, pp. 12751– 12753 (1997) CBL@NCU
Life Science + Physics 很好玩 謝謝大家! • 歡迎寒暑假來玩 • 歡迎來上中央大學 – 黎璧賢老師 pylai@phy. ncu. edu. tw – 陳方玉老師 fychen@phy. ncu. edu. tw – 陸駿逸老師 dlu@phy. ncu. edu. tw – 李弘謙老師 hclee@phy. ncu. edu. tw http: //www. phy. ncu. edu. tw/hclee/index_eng. htm
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