Biophotonics at the University of California Merced Jay

Biophotonics at the University of California - Merced Jay E. Sharping, Assistant Prof. in Physics UC BIOPHOTONICS ALLIANCE

A lot has changed in the past 10 years in Merced!

Biophotonicists at UC Merced use light in a clever* manner • We equip our research projects with… – Technology: sources, detection schemes, and integrated systems – For applications in: Microscopy, cell manipulation, biodiversity, quantitative biochemical analysis

Strengths (in addition to physics) • • • Stem cell and cancer research Applied math / computational sciences Climate change Solar and renewable energy Water quality and resources

Notable researchers Arnold Kim Ariel Escobar Jennifer Lu Jing Xu Jinah Choi Teamrat Gherazzi Andy Li. Wang Linda Hirst Wei-Chun Chin Anne Kelley Dan Hirleman Patti Li. Wang

Professor Arnold D. Kim Research: Theoretical and computational biophotonics Light propagation in tissues Direct images Reconstructed images Depth of absorbing plate Light scattering by nano-scale rough surfaces Backscattered intensity

Scattering for bacterial pathogen ID

Fiber-based optical trapping (Tessa Pinon with Linda S. Hirst) Parafilm Jacketed fiber Tape Bare fiber tips

Phosphorylation cycle in clock proteins Andy Li. Wang Study of the mechanisms of this rhythm • FRET • Fluorescence anisotropy

Binding of v. CCI (viral CC chemokine inhibitor) with chemokines – Patti Li. Wang Studies • HIV inhibitors • Fundamentals of protein operation Outreach • Army grant for minority serving institutions • AGEP (Alliances for Graduate Education and the Professoriate) • Mc. Nair scholars

J. Choi – UCM Chemical Jan 2012 and Virus-Host Interactions of Hepatitis C Virus & Liver Disease • Alcohol and HCV: - Role of lipid metabolism in the potentiation of HCV replication by alcohol - Genotoxicity, positive selection, and mutation rate of RNA viruses • Pathogenesis of hepatocellular carcinoma: - Role of hepatocyte NAD(P)H oxidases and inflammation • Mechanism of immune escape: - Modulation of pattern recognition receptor signaling - Role of translational frameshift/alternate frames decoding

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