Bioortogonal catalysis for cancer therapy TAGWORKS Presentation MidTerm

Bio-ortogonal catalysis for cancer therapy TAGWORKS Presentation Mid-Term Check Meeting Edinburgh, 5 th June 2019 Raffaella Rossin, Ph. D CSO of Tagworks Innovative Training Networks (ITN) – Marie Skłodowska-Curie Actions H 2020 -MSCA-ITN-2017 (THERACAT-765497)

Institution description Tagworks aims to revolutionize cancer therapy: controlled release & activation of highly potent chemotherapeutics in the tumor microenvironment. Spun out of Philips Healthcare in 2012, Tagworks is a preclinical stage biotech with ownership of a broad IP estate on Click-pretargeting and Click-to-Release technologies. + + NH 2 CO 2 tc-ADC + activator tc-ADC vc-ADC activator vehicle Innovative Training Networks (ITN) – Marie Skłodowska-Curie Actions H 2020 -MSCA-ITN-2017 (THERACAT-765497)

Institution description In vivo unmasking & activating proteins and particle catalysts cleavage site mask PEG Innovative Training Networks (ITN) – Marie Skłodowska-Curie Actions H 2020 -MSCA-ITN-2017 (THERACAT-765497)

Research group Marc Robillard, Ph. D CEO Bio-inorganic chemist Raffaella Rossin, Ph. D CSO Radiochemist Thuur van Onzen, Ph. D Senior scientist Organic chemist Laurens Kleijn, Ph. D Senior scientist Organic chemist Martijn den Brok, Ph. D Senior scientist Immunologist ESR 12 -TAG: Maria Vlastara Contract start date: 15/01/19 Contract end date: 14/01/22 Partners: Radboud University MC, Sy. MO-Chem, Syncom Innovative Training Networks (ITN) – Marie Skłodowska-Curie Actions H 2020 -MSCA-ITN-2017 (THERACAT-765497)

Role within the network Training Events TE 4 – Going in vivo, chemistry and cancer biology. Month 30 • General introduction on in vivo nanoparticle and macromolecule nuclear imaging • Bioorthogonal chemistry for cancer imaging • In vivo nanoparticle catalyst activation and imaging TE 5 – Getting ready for the next career step. Month 36 • How to launch your own start-up (and survive) • Interview simulations Secondments at TAG Steven Croke (EDI): Months 27 -30 Shreyas Wagle (TAU): Months 36 -39 Innovative Training Networks (ITN) – Marie Skłodowska-Curie Actions H 2020 -MSCA-ITN-2017 (THERACAT-765497)