Biomaterials Research Manfred Maitz The Blood Clotting Cascade
Biomaterials Research - Manfred Maitz The Blood Clotting Cascade Manfred Maitz FZ-Rossendorf www. manfred. maitz-online. de
Biomaterials Research - Manfred Maitz The Clotting Cascade Thrombin Fibrin polymers Fibrin monomers Fibrinogen
Biomaterials Research - Manfred Maitz The Clotting Cascade Intrinsic Pathway Extrinsic Pathway Surface Contact Collagen FXII activator F XII Tissue/Cell Defect F XIIa F XI F IXa Ca 2+ F VII F III (Tissue Thromboplastin) F VIIIa Platelet Factor 3 Factor F X Ca 2+ Factor F Xa F Va Prothrombin I F XIIIa Crosslinked Fibrin Meshwork Ca 2+ F XIa Ca 2+ F IX F VIII F VIIa Ca 2+ Factor F X FV Thrombin F XIII Fibrin polymers Fibrin monomers Fibrinogen
Biomaterials Research - Manfred Maitz Serine Proteases RN O RN C : O O- Ser H HN C O HN Ser H RC RC Tetraedric Transition State Break of the Peptide Bonding HN H RC RN RN H 2 O C : O Release of the H N-terminal peptide O OH Ser O C O Enzyme-acetyltransition-state Ser
Biomaterials Research - Manfred Maitz The Fibrinolytic System Clotting Cascade Fibrinogen Fibrin degradation products Fibrin-clot Plasminogen T-PA F XIIa HMWK Kallikrein Urokinase Streptokinase Plasmin
Biomaterials Research - Manfred Maitz Effect of Antithrombin III/Heparin Intrinsic Pathway Extrinsic Pathway Surface Contact Collagen FXII activator F XII Tissue/Cell Defect F XIIa F XI F IXa Ca 2+ F VII F III (Tissue Thromboplastin) F VIIIa Platelet Factor 3 Factor F X Ca 2+ Factor F Xa F Va Prothrombin I F XIIIa Crosslinked Fibrin Meshwork Ca 2+ F XIa Ca 2+ F IX F VIII F VIIa Ca 2+ Factor F X FV Thrombin F XIII Fibrin polymers Fibrin monomers Fibrinogen
Biomaterials Research - Manfred Maitz Thrombin Time (TT) Intrinsic Pathway Extrinsic Pathway Surface Contact Collagen FXII activator F XII Tissue/Cell Defect F XIIa F XI F IXa Ca 2+ F VII F III (Tissue Thromboplastin) F VIIIa Platelet Factor 3 Factor F X Ca 2+ Factor F Xa F Va Prothrombin I F XIIIa Crosslinked Fibrin Meshwork Ca 2+ F XIa Ca 2+ F IX F VIII F VIIa Ca 2+ Factor F X FV Thrombin F XIII Fibrin polymers Fibrin monomers Fibrinogen
Biomaterials Research - Manfred Maitz The Quick (PT)-Test Intrinsic Pathway Extrinsic Pathway Surface Contact Collagen FXII activator F XII Tissue/Cell Defect F XIIa F XI F IXa Ca 2+ F VII F III (Tissue Thromboplastin) F VIIIa Platelet Factor 3 Factor F X Ca 2+ Factor F Xa F Va Prothrombin I F XIIIa Crosslinked Fibrin Meshwork Ca 2+ F XIa Ca 2+ F IX F VIII F VIIa Ca 2+ Factor F X FV Thrombin F XIII Fibrin polymers Fibrin monomers Fibrinogen
Biomaterials Research - Manfred Maitz Partial Thromboplastin Time [(a)PTT] Intrinsic Pathway Extrinsic Pathway Surface Contact Collagen FXII activator F XII Tissue/Cell Defect F XIIa F XI F IXa Ca 2+ F VII F III (Tissue Thromboplastin) F VIIIa Platelet Factor 3 Factor F X Ca 2+ Factor F Xa F Va Prothrombin I F XIIIa Crosslinked Fibrin Meshwork Ca 2+ F XIa Ca 2+ F IX F VIII F VIIa Ca 2+ Factor F X FV Thrombin F XIII Fibrin polymers Fibrin monomers Fibrinogen
Biomaterials Research - Manfred Maitz Surface Sensitive Steps Intrinsic Pathway Extrinsic Pathway Surface Contact Collagen FXII activator F XII Tissue/Cell Defect F XIIa F XI F IXa Ca 2+ F VII F III (Tissue Thromboplastin) F VIIIa Platelet Factor 3 Factor F X Ca 2+ Factor F Xa F Va Prothrombin I F XIIIa Crosslinked Fibrin Meshwork Ca 2+ F XIa Ca 2+ F IX F VIII F VIIa Ca 2+ Factor F X FV Thrombin F XIII Fibrin polymers Fibrin monomers Fibrinogen
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