Biomaterials Functional Tissue Engineering Stephanie J Bryant Chemical
Biomaterials & Functional Tissue Engineering Stephanie J. Bryant Chemical & Biological Engineering; Material Science & Engineering; Bio. Frontiers Institute 2. The Foreign Body Response 1. Synergism Between Biochemical Cues & Mechanical Forces -> Physiochemical Cues External Mechanical Forces Hydrogels Tissue-Specific cells Hydrogel Niches Vasculature Mimetics Osteochondral Mimetic Hydrogels Designing Materials to Enable Functional Tissue Engineering In Vivo Hydrogel Inflammation Fibrosis 3. Personalizing Tissue Engineering Dynamic Tension Dynamic Compression Bioreactors Patient-specific hydrogel designs Tissue Regeneration
Designing Scaffolds for Regeneration & Function: Musculoskeletal Applications Clinical Problem: Restoring Function: Focal cartilage defect 3 D Printing: Stereolithography Native Cartilage Injectable Degradable & Biomimetic Hydrogel w/ Stem Cells Tissue Regeneration: Tissue-Inspired Designs = Stem Cells Dynamic Compression Synthetic Hydrogels w/ Extracellular Matrix Molecules & Growth Factors Hyaline Cartilage Fibrocartilage Hypertrophic Cartilage
Designing Scaffolds for Regeneration & Function: Vasculature Applications Clinical Need for Hemodialysis Access and our Solution: PCRN-Graft PCRN: Precision Cell-Regenerative Niche Ø 450, 000 in US Ø Failure Rate is 40 -80%
The Role of Foreign Body Response (FBR) In Tissue Engineering and How to Combat the FBR? Biomaterial Protein adsorption Neutrophils & Macrophage interrogation and attack Poly(ethylene glycol) Hydrogel: k. Da 250 100 75 Protein adsorption 50 37 25 Mac 3 (brown) = macrophage Dense, avascular collagen capsule 28 days 2 days Classically-activated macrophages 30 min Biomaterial Fibrous Capsule * Mac 3
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