BIOE 301 Lecture 7 How are new technologies
BIOE 301 Lecture 7 How are new technologies developed? 02. 07 Jenni Greeson
Four Questions • What are the problems in health care today? • Who pays to solve problems in healthcare? • How can we use science and technology to solve healthcare problems? • Once developed, how do new healthcare technologies move from the lab to the bedside?
Unit 3: How can technology be used to solve health care problems? • Where do innovations come from? • Three case studies showcasing the development and refinement of health care innovations – Prevention of infectious disease – Early detection of cancer – Treatment of heart disease
Today’s Focus: The process of developing a new medical technology Goals: • Describe the scientific method • Describe the engineering method • Contrast the two • Take-apart activity
Science vs. Engineering
Science 1. 2. A branch of knowledge or study dealing with a body of facts or truths systematically arranged and showing the operation of general laws: the mathematical sciences. Systematic knowledge of the physical or material world gained through observation and experimentation. www. dictionary. com 3. The underlying goal or purpose of science to society and individuals is to produce useful models of reality. www. wikipedia. org
Engineering 1. The art or science of making practical application of the knowledge of pure sciences, as physics or chemistry, as in the construction of engines, bridges, buildings, mines, ships, and chemical plants. www. dictionary. com 2. 3. The design, analysis, and/or construction of works for practical purposes. Engineers use their knowledge of science, mathematics, and appropriate experience to find suitable solutions to a problem. www. wikipedia. org
Science • Seeks to explain the world around us • Inquiry based • No practical goal necessary • Scientific method Engineering • Seeks to solve a specific problem • Need based • Must be practical – Constraints • • Time $$ Performance Reliability • Engineering design method
Scientific Method Steps Pose a question Example Why do cut apples turn brown? Generate a hypothesis Cut apples turn brown because of an interaction between something in the air and something on the inside of the apple. Design experiments to test the hypothesis Place uncut and cut apples in two different environments 1. Control 2. Vacuum (air-free) Carry out experiments; analyze data Results: Uncut Vacuum Uncut Air Cut Vacuum Cut Air Revise the hypothesis if Our hypothesis was correct, but we can now extend it to necessary learn more about what “things” are involved in the interaction.
In case you’re curious … • Apples (and other produce) contain an enzyme called tyrosinase. • Tyrosinase reacts with phenols (also found in the apple) and with oxygen when the fruit is exposed to produce a form of rust. • Ways to prevent or slow the reaction: – Inactivate the enzyme with heat – Reduce the p. H on the apple’s surface (lemon juice) – Reduce the amount of available oxygen (vacuum pack; submerge in water)
Engineering Design Method Identify a need Define the problem Generate design specifics Gather information Develop solutions Evaluate solutions Communicate results
Engineering Design Method Example – Hearing Aids October 18, 2006 – The World Health Organization (WHO) and WWHearing (World Wide Hearing Care for Developing Countries) agreed to work together to encourage and enable provision of affordable hearing aids and services on a massive scale, especially in developing countries and underserved communities.
Example - Hearing Aids Step 1: Identify a need • Hearing loss can greatly impact quality of life – Adults: productivity loss – Children: delayed development • Most prevalent, yet preventable, disability in the world • 80% of deaf and hearing-impaired people live in lowand middle-income countries • Current production of hearing aids is 1/10 th of global need; only 25% are distributed to developing countries • <1 in 40 people in developing countries have the hearing aids they need • 50% of deafness and hearing impairment is avoidable through prevention, early diagnosis, and management
Example – Hearing Aids Step 1: Identify a need (cont’d) • Causes of hearing impairment before or during birth: – Genetic – Premature birth – Rubella, syphilis or certain other infections in a woman during pregnancy – The use of ototoxic drugs (gentamicin) – Jaundice • Other causes: – Infectious diseases (meningitis, measles, mumps and chronic ear infections) – Use of ototoxic drugs at any age, including some antibiotic and anti-malarial drugs – Excessive noise
Example – Hearing Aids Step 2: Identify a need • Ways to prevent hearing loss – Improve antenatal and perinatal care – Immunize children (measles, meningitis, rubella and mumps) – Immunize women of child-bearing age against rubella before pregnancy – Test and treat syphilis and certain other infections in pregnant women – Avoiding the use of ototoxic drugs unless necessary and closely monitored – Refer jaundiced babies for diagnosis and treatment – Reduce loud noise exposure • Ways to treat hearing loss – Increase availability of affordable, fitted hearing aids
Example – Hearing Aids Step 2: Define the Problem & Determine Specifications Problem: Increase availability of affordable, fitted hearing aids WHO Initiative Specifications: • Priority given to children (21 -80 d. BHL) followed by adults (41 -80 d. BHL) • Behind the ear aids preferred • Aids must meet minimum performance specifications • Manufacture or assembly of aids should be feasible in developing countries • Batteries should be zinc air or rechargeable • Ear molds should be custom made and easily replaced at recommended intervals • Keep costs low
Example – Hearing Aids Step 3: Gather Information • What current hearing aid designs are available? • Where do the current designs fail (in developing countries)? – – Too expensive Inappropriate design Ear mold customization Batteries
Example – Hearing Aids Step 4: Develop Solutions • Engineer a better way to customize ear molds – Need a better way of creating negative ear mold – Current method uses plaster of Paris; imprints must be delivered in days to avoid shrinkage – Difficult in underdeveloped areas that are far from mold manufacturing facilities New method might use an engineered material that does not shrink New method might enable delivery of “mold” electronically, eliminating travel time
Example – Hearing Aids Step 5: Evaluate Solutions • How well are product specifications met? • In our case, new technologies to produce ear molds must conform with overall specifications for success in delivering hearing aids to developing countries. Step 6: Communicate Results • Optimal solution is selected
Scientific Method • Pose a question • Generate a hypothesis • Design experiments to test hypothesis • Carry out experiments • Revise hypothesis; if necessary Engineering Design Method • Identify a need • Define the problem – Generate specifications • • Gather information Develop solutions Evaluate solutions Communicate results
References • General hearing loss statistics http: //www. wi-shhh. org/hearing_loss_statistics. htm • Specifics on the WHO and WWHearing initiative http: //www. who. int/mediacentre/factsheets/fs 300/en/index. html http: //whqlibdoc. who. int/publications/2004/9241592435_eng. pdf
Take-apart Activity
• Project task I due today • Project task II due 02/08 • HW 4 due next time 02/06
- Slides: 25
