Bioactivity of inorganic compounds Department of Pharmaceutical Chemistry
Bioactivity of inorganic compounds Department of Pharmaceutical Chemistry https: //www. vnmu. edu. ua/en/department/8#
The course is designed to establish a connection between theoretical disciplines of the first year of study (Latin, general and inorganic chemistry, anatomy and physiology, biology with the basics of genetics) and subjects of the training cycle: • pharmacotherapy with pharmacokinetics • pharmacology • pharmaceutical chemistry • toxicological and forensic chemistry • drug toxicology
The purpose of the course • formation of the scientific worldview of applicants for higher education, the development of modern forms of theoretical thinking and the ability to analyze phenomena; • formation of skills and abilities for application of chemical laws and processes in future practical activity; • study of the role of chemical elements in the physiological processes of living organisms; • competent use of chemicals and materials in the pharmaceutical industry.
The objectives of the discipline are to acquaint students with: • classification of chemical elements according to their content in the body, biological role and according to their position in the Periodic Table; • the use of physiologically active substances based on inorganic, coordination and organometallic compounds in medicine as drugs and cosmetics, biomaterials, bioprobes, radiopharmaceuticals; • foods that are used for therapeutic diets in the absence of the element in the body. • mechanisms of toxicity of exogenous compounds of metals xenobiotics; • approaches to detoxification and the search for detoxifying agents to solve specific problems in the field of pharmacy, in accordance with modern requirements.
The structure of the discipline • 1. The role of chemical elements in human life. • 2. Bioelements - organogens. Oxygen. Carbon. Hydrogen. Nitrogen. • 3. Bioelements - macronutrients. Calcium. Phosphorus. Sulfur. Potassium. Sodium. Chlorine. Magnesium. • 4. Bioelements - vital microelements. Iron. Zinc. Copper. Manganese. Molybdenum. Cobalt. Chrome. Selenium. Iodine. • 5. Conditionally vital trace elements. Fluorine. Boron. Silicon. Nicole. Vanadium. Bromine. Arsenic. Lithium. • 6. Potentially toxic trace elements. Rubidium. Zirconium. Stanum. Argentum. Aurum. Tungsten. Germanium. Gallium. Strontium. Titanium. • 7. Toxic trace elements. Aluminum. Plumbum. Barium. Bismuth. Cadmium. Mercury. Thallium. Beryllium. Antimony.
As a result of studying the discipline the student must know: • vital elements, their physicochemical properties and position in the Periodic Table; • main features, structure and functions of metalloproteins; • types of interaction of metals with proteins, nucleic acids, carbohydrates, lipids and other natural compounds; • the most important drugs of inorganic nature used in medical practice; • main symptoms of deficiency, excess and toxicity of exogenous compounds; • basic principles of a balanced diet.
As a result of studying the discipline the student must be able to: • to interpret the general laws underlying the use of inorganic substances in pharmacy and medicine; • apply theoretical foundations of general and inorganic chemistry and acquired experimental skills in the study of specialized disciplines. • classify elements according to their content in the body: macronutrients, trace elements, ultramicroelements; • determine the relationship between the toxicity of elements and their compounds with the electronic structure and form of compounds.
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