Bioactive Flavonoids and Catechols as Hif 1 and
Bioactive Flavonoids and Catechols as Hif 1 and Nrf 2 Protein Stabilizers Implications for Parkinson&#x 02019; s Disease Smirnova Natalya A. , Kaidery Navneet Ammal, Hushpulian Dmitry M. , Rakhman Ilay I. , Poloznikov Andrey A. , Tishkov Vladimir I. , Karuppagounder Saravanan S. , Gaisina Irina N. , Pekcec Anton, Leyen Klaus Van, Kazakov Sergey V. , Yang Lichuan, Thomas Bobby, Ratan Rajiv R. , Gazaryan Irina G. of Cornell University, White Plains, NY 10605, USA 2 D. 1 Burke Medical Research Institute, Weill Medical College Rogachev Federal Scientific and Clinical Center for Pediatric Hematology, Oncology, and Immunology, Moscow 117997, Russia 3 Departments of Pharmacology, Toxicology &#x 00026; Neurology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA 4 Valenta. Pharm, Moscow 119530, Russia 5 Department of Chemical Enzymology, Moscow State University, Moscow 119992, Russia 6 Department of Medicinal Chemistry and Pharmacology, University of Illinois at Chicago, IL 60612, USA 7 Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA 8 Department of Chemistry and Physical Sciences, Dyson College, Pace University, Pleasantville, NY 10570, USA. Figure 1. Schematic presentation of a luciferase-labeled surrogate transcription factor reporter. K o , rate of fusion protein generation, &#x 0201 C; promoter capacity&#x 0201 D; , k 1 , rate constant for the recognition step, which has been shown to be rate-limiting for the reporters under discussion, K i , inhibition constant for a stabilizer working at the first step; k 2 , ubiquitinylation rate constant; k 3 , proteasomal degradation rate constant. Aging and Disease, 2016, 7(6), 745 -762. DOI: 10. 14336/AD. 2016. 0505
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