Bio StructX Matthias Wilmanns Project Coordinator EMBL Hamburg

Bio. Struct-X Matthias Wilmanns, Project Coordinator, EMBL Hamburg Ivana Custic, Project Manager, EMBL Hamburg Johannes Schmidt, IT project coordinator http: //www. biostruct-x. eu/ 1 6/12/2021 © EMBL 2011 1

Bio. Struct-X Project Tasks TNA support for 44 installations: § § Biological small angle X-ray scattering (5) macromolecular X-ray crystallography (26) Biological X-ray imaging (4) Protein production and HTP crystallisation (9) Level of funding: 60% 4 selected Joint Research Activities: § To enhance methods integration § Integration of emerging facilities (XFELs) and emerging methods (X-ray imaging) Level of funding: 28% § Centralised (via providing facilities) and decentralised (via TID centres) training and networking activities. 2 6/12/2021 © EMBL 2011

Bio. Struct-X Key Features • TNA access focused on X-ray based structural biology (WP 2 -WP 4) • Includes sample production, characterization, crystallization (WP 5) • Unified portal for Block Allocation Group (BAG) project applications • Centralized proposal evaluation • Partner facilities provide project access and Bio. Struct-X support, reflecting Bio. Struct-X panel evaluations 3 6/12/2021 © EMBL 2011

Bio. Struct-X infrastructure timeline Summer 2011 Local EMBL HH IT group in charge of technical implementation Outsource of CMS and proposal form implementation 4 01. 09. 2011 Start of Bio. Struct-X project, project officer starts Oct. 2011 1 st version Bio. Struct-X application form available March 2012 First project evaluation conference June 2012 First implementation phase finishes

Notification workflow diagram 5

Bio. Struct-X challenges • Duplicated proposal procedures is a burden for the users • Match of project and user identities in Bio. Struct. X and facility systems • Collection of facility-relevant proposal parameters necessary? 6 6/12/2021 © EMBL 2011

Roadmap • Enable Umbrella login • Agree on a set of facility-relevant parameters • Offer extraction of relevant proposal information • „private“ goal to create local user accounts automatically 7 6/12/2021 © EMBL 2011

Umbrella@EMBL Hamburg • Communication and acceptance vital • Integrity and confidentiality questions • ? Do we need another user portal? 8 6/12/2021 © EMBL 2011

(addendum) What is a Bio. Struct-X BAG? 9 • BAG stands for “Block Allocation Group”, a form of collective project proposals, established at many synchrotron facilities in Europe, including the ESRF • Bio. Struct-X prefers applications from multiple research groups or consortia (regions, countries), to allow effective application and evaluation procedures. • Single project proposals are excepted. Bio. Struct-X may make suggestions for joining existing consortia. • Each BAG consists of one BAG coordinator, one deputy, and a list of principal investigators, with specific projects associated. • Each BAG may apply for access for one or more platforms at one or more Bio. Struct-X partner facilities 6/12/2021 © EMBL 2011