Bentuk Sediaan Obat Motivation Decision support Chronic disease
Bentuk Sediaan Obat
Motivation • Decision support • Chronic disease management guidelines • Computer needs to be able to answer questions such as : • “Is this patient on an inhaled steroid for asthma? ” • “on a sustained release tablet for angina? ” • Implies machine has explicit categorisation of drugs by Indication, Chemical structure, Route of admin, Form, etc.
Patient on • Becodisks • Dry powder for inhalation, disks containing 8 blisters of beclometasone dipropionate • 100 micrograms/blister
Forms proposed Spray. Dermal Spray. Inhalant Powder. . . Inhalant Powder Capsule. . Nasal Inhalant. . Oral Inhalant. Nasal Spray with Adaptor. Powder Spray. . Inhalant Powder Capsule
Inhaled steroid for asthma Route – implies some forms Aerosol, Dry powder Drug class Indication
‘Form’ in reality Route of administration Physical Form + Administration Action + Administration Device Ø Ø Inhaled Powder Form for chewing Delivered by applicator
Route taxonomy. . . . topical to conjunctiva topical to ear topical to nose topical to skin topical to scalp topical to oral mucosa. buccal sublingual topical to teeth oral (passing through oral cavity) rectal vaginal intravenous intrathecal intraperitoneal inhaled to lung via nose. inhaled to lung via mouth
Drug form taxonomy. . . . . aerosol bar cake disk foam gel. jelly gum liniment liquid. Emulsion lotion ointment particulate. bead. crystal. flake. granule. pellet. powder. suppository . paste. patch. pill. Shaped. . caplet. . capsule. . tablet. . . lozenge. . . pastille. . troche. semi. Solid. Emulsion. . cream. solution. . aqueous. . . elixir. . . syrup. . oil. stick. suspension. wafer
Device taxonomy. spray device. drug applicator. drug dropper device
Process/Action taxonomy. . Douching Rinsing Irrigating Spraying Liquid installing. Infusing. Irrigating Chewing Inhaling Ingesting
4 hierarchies of ‘form’ By Route By Physical Form . 'inhaled to lung form'. . 'Inhalation Solution'. . 'Nasal Inhalant'. . 'Oral Inhalant'. . 'Inhalant Powder'. . . 'Inhalant Powder Capsule‘ . 'Solid'. . 'Powder'. . . 'Powder Spray'. . 'Inhalant Powder'. . . 'Inhalant Powder Capsule'. . . 'Powder for Reconstitution‘ By Action By Device
'Sustained Release Buccal Tablet' Intermediate Representation : MAIN tablet HAS_PHARMACOKINETICS sustained release HAS_ROUTE buccal
'Sustained Release Buccal Tablet' First parent : Form classification: From form taxonomy: 'Solid‘. 'Pill‘. . 'Tablet‘. . . 'Sustained Release Buccal Tablet' pill. Shaped. . caplet. . capsule. . tablet. . . lozenge. . . pastille. . troche
'Sustained Release Buccal Tablet’ second parent : Route classification From route taxonomy . 'oral mucosa form'. . 'buccal form' Route. topical to conjunctiva. topical to ear. topical to nose. topical to skin. topical to scalp. topical to oral mucosa . . . 'Sustained Release Buccal Tablet' . . buccal n. b. Pharmacokinetics – sustained release is another classification concept
Where now? • Preliminary work • Quick classification of the leaf terms supplied • Intermediate nodes from Prodigy work Chris Wroe [wroec@cs. man. ac. uk] http: //www. cs. man. ac. uk/mig/people/wroec/index. html
- Slides: 15