Bell Work 1 Turn in your virus drawing

Bell Work: 1. Turn in your virus drawing • Title: Virus Replication • Date 2/4/2016 • EQ: How do viruses replicate? End www. A 6 training. co. uk

What is the drug called that inhibits reverse transcription of HIV? AZT

Are Viruses Alive? NO Why? They need a host cell to reproduce

No longer accepted: Cladogram HW Shark WS Fungi WS Taxonomy WS Turn in for 70: Kingdom Sort Due Today: Virus Drawing

Quiz Tomorrow!

Today’s Standard (B. 4 C): compare the structures of viruses to cells, describe viral reproduction, and describe the role of viruses in causing diseases such as HIV and influenza. Essential Question: How does a virus reproduce?

Essential Question: How does a virus reproduce? Standard: describe viral reproduction (B 4 C)

When a virus invades…

Number the ovals on your paper 1 2 6 3 7 4 8 5

Lysogenic Cycle

Lysogenic Cycle 1. 2. 3. 4. Attach to cell Inject DNA/RNA Integrate/Join virus DNA into cell’s DNA Wait while cell grows and divides (latency) (Cell is not being destroyed in the lysogenic cycle) 5. Remove virus DNA/RNA Become active (write on arrow connecting 5 and 6)

In the lysogenic cycle the virus become dormant Dormant- having normal physical functions suspended or slowed down for a period of time; in or as if in a deep sleep.

- Viruses Lysogenic Cycle

Example HIV Write this on the right of your paper (by oval 3) • Enveloped RNA virus • Waits for months to years • Over time the destruction of white blood cells allows people to get sick from other diseases

HIV (arrows) Infecting a T-lymphocyte

Transmission

Create an analogy……… The Lysogenic Cycle is like a ______ because _____.

Lytic Cycle

Lytic Cycle 1. Attach to cell 2. Inject DNA/RNA 6. Produce (replicate) virus parts 7. Assemble new virons 8. Release viruses to infect other cells (lyse/lysis) (Cell is being destroyed)

- Viruses Lytic Cycle

Which part of the lytic cycle is shown below?

Example Influenza A Write this on the right of your paper (by oval 6) • Enveloped virus with a segmented RNA • Symptoms appear within days • Infects a wide range of animals other than humans • Undergoes extensive mutations • Causes the flu

Spread of influenza virus

Weekly consultation rates for influenza and influenza-like illness: Weekly Returns Service of the Royal College of General Practitioners, 1988 to 1999 600 Rate per 100 000 population 500 Epidemic activity 400 300 200 Higher than expected seasonal activity Baseline activity Normal seasonal activity 100 0 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 Year CDR Weekly Report: 5 th November 1999

Create an analogy……… The Lytic Cycle is like a ______ because ______.

Sage and Scribe: Cycle Steps • Get into partners—decide who is partner A and who is partner B. – Partner A: Describe the steps for the Lytic cycle. – Partner B: Draw each step. • After a few minutes, we will switch to the Lysogenic Cycle and you will switch roles.

Comic Strip • Create a comic strip to describe a viral reproduction cycle. – If you are at a “Red”, you are doing the lysogenic cycle. – If you are at a “Black”, you are doing the lytic cycle. • Your comic should be 6 “slides”, colored, and be the cycle in STORY format