Bell Ringer Blood Punnett Squares 1 Cross AB

Bell Ringer: Blood Punnett Squares: 1. Cross AB Blood with Heterozygous B Blood. What are the results/possibilities? 2. Cross Homozygous A Blood with Heterozygous B Blood. What are the results/possibilities? 3. Cross O Blood with Heterozygous A Blood. Is there a possibility of O Blood?

Joke of the Day:

Pedigrees

Pedigree Chart that shows the relationships between a family.

Roman Numerals Represent the Family Generations Pedigrees A circle represents a female. I A horizontal line connecting a male and female represents a marriage. II A half-shaded circle or square indicates that a person is a carrier of the trait. III A completely shaded circle or square indicates that a person expresses the trait. A square represents a male. A vertical line and a bracket connect the parents to their children. A circle or square that is not shaded indicates that a person neither expresses the trait nor is a carrier of the trait.

Sample Pedigree • 1. This pedigree shows the inheritance of attached ear lobes. Which parent has attached ear lobes? • 2. How many children do the parents have? Which child has attached ear lobes? • 3. Which child is married? Does this child’s spouse have attached ear lobes? Do any of this child’s children have attached ear lobes? n = Attached Earlobes N = Free Earlobes I II III

Benjamin Stacy - born 1975

The Blue People of Troublesome Creek Eastern Kentucky in 1820.

Meet the Fugates… • Martin Fugate had methemoglobinemia, a condition that results in abnormal hemoglobin

Meet the Fugates • A symptom of this condition is “blue skin” which is due to the absence of the enzyme diaforase, a necessary enzyme that converts methemoglobin to hemoglobin • Martin married a carrier of the disease and they bore seven children; four of which were blue • The condition is inherited as a recessive trait and would appear most often in an inbred line

Fugate Pedigree

Benjamin Stacy - born 1975

Not in any way related to these guys.

Geographic Isolation… • The people of Troublesome Creek were isolated from the rest of the country. When the town was settled there were no roads, making it hard to get out and people tended to intermarry • One of Martin’s sons married his maternal aunt and 100 years later Benjy Fugate was born • As railroads and development swept through, the blue Fugates started moving out of Troublesome Creek and marrying other people • The inherited blue began to disappear as the recessive gene spread to families where it is unlikely to be paired to a similar gene

Hemophilia: “The Royal Disease”