BD Presentation David Malek VP Business Development Bio

BD Presentation David Malek, VP Business Development Bio. Line. Rx davidm@biolinerx. com 054 -5300366

Forward Looking Statements This presentation contains "forward-looking statements. " These statements include words like "may, " "expects, " "believes, " “plans, ” “scheduled, " and "intends, " and describe opinions about future events. These forward-looking statements involve known and unknown risks and uncertainties that may cause the actual results, performance or achievements of Bio. Line. Rx to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. 2

Bio. Line. Rx - General • Founded in 2003 by Teva and other key players in Israeli Life Sciences industry • Bridge “development gap” for Israeli assets – Leverage carefully selected early-stage technology, primarily at academia level, following proof of concept in animals (at a minimum) – Invest 3 -6 years in asset through to major catalyst – Partner the asset (depending on the stage) • Current pipeline of 10 assets, 6 in clinical development • ~55 employees, of which ~40 with advanced degrees 3

Efficient Project Development Infrastructure Expert Project Managers BD In-licensing and Out-licensing Medical and Clinical Team Multiple Projects Chemistry Team (Organic, Analytical, Bioanalytical, Formulation) Pre-Clinical Team Intellectual Property Experts Regulatory Affairs Team 4

WHAT IS BD IN BIOPHARMA COMPANIES? EXAMPLE VIA BIOLINERX 6

In Bio. Line. Rx, BD Has 3 Major Responsibilities • Scouting & in-licensing – Search for innovative and attractive projects, in Israel and abroad – Evaluate projects: science, development, clinical need, commercial opportunity, IP – Negotiate with inventors and manage the alliance • Out-licensing – The way in which most companies make revenues – Identify partners, contact them, present and persuade, manage relationship – Negotiate and manage the alliance • “Commercial Sense” – Identify best value for the project from the commercial perspective – Collaborate with R&D to find overlap between commercial potential, scientific fit and development feasibility – Continuously monitor and analyze the impact of changes in the market/data 7

The Team Structure Supports These Roles Gideon Stein Lior Teitelbaum Victoria Balannik • Scout • Portfolio Manager • Scientific Evaluation Leader Tomer Bahar • Out Licensing Inbal Michaelovici • Analyst 8

CAREER PATHS TO BD ROLES 9

What is the Background of the Team Members? Gideon Stein Lior Teitelbaum Victoria Balannik • Education: MD, MBA • Experience: physician, entrepreneur • Education: MSc. , MBA • Experience: VC analyst, small medical device company • Education: Ph. D • Experience: Post-doc, researcher, Amazon Tomer Bahar • Education: MSc. , MBA • Experience: Pw. C, Hadasit Inbal Michaelovici • Education: Ph. D • Experience: Researcher 10

What Are the Key Career Paths? • Direct to industry – Typically junior – Better chance at companies with larger BD teams, TTOs • Investment community – Relatively few positions, more in the lines of temporary experience – Typically analyst positions • R&D first – Work for several years in R&D roles and try to “progress” to BD – Typically easier within the same company – Can also work for entrepreneurs • Service Industry – “satellite” companies supporting the industry: IP law firms, accounting firms, etc. 11

? מה לעשות , תכל'ס • Read business news and literature all the time – Free sources are fine: Fierce. Biotech, First. Word, etc. • Gain as wide a base as possible in your academic experience – In BD, over-specialization is typically NOT a good thing – Show you’re a fast-learner (which you’ll need to be in order to switch to business) • Get some part-time experience/project – Create some level of confidence and differentiation – You will learn a lot about the fit • Network (with the relevant people) – Strong labs/recommendations help • MBA: only if you really want to • Don’t be afraid to take tasks that you have no experience/qualifications for 12