BCLC Outperforms HKLC Staging of Hepatocellular Carcinoma in

BCLC Outperforms HKLC Staging of Hepatocellular Carcinoma in Multiethnic Asians – Real-World Perspective ESPS Manuscript NO: 32584

Figure 1 a. Barcelona Clinic Liver Cancer (BCLC) staging system 2

Figure 1 b. Hong Kong Liver Cancer (HKLC) staging system 5

Figure 2 a. Kaplan-Meier survival curve according to BCLC staging system Cumulative Survival BCLC 0 5 10 15 Survival Time (Years) 20 25

Figure 2 b. Kaplan-Meier survival curve according to HKLC staging system Cumulative Survival HKLC 0 5 10 15 20 Survival Time (Years) 25 30

Percentage Figure 3. Patients receiving curative treatment after assignment to curative treatment groups by BCLC and HKLC staging systems BCLC Curative Stages 0 and A BCLC Stage 0 *Figures in percentage BCLC Stage A HKLC Curative Stages I, II and Va HKLC Stage II HKLC Stage Va

Figure 4. Comparison of characteristics of patients assigned by HKLC staging system to curative treatment who did and did not receive recommended treatment p < 0. 001 Received Curative Treatment Did not Received Curative Treatment 100 92% 87. 5% 90 Age (in years) / Percentage 80 p < 0. 001 73. 2% 70 60 65. 5 60 p < 0. 001 47. 8% 50 41. 4% p < 0. 001 40 30 p < 0. 001 26. 8% 20 10. 7% 8. 0% 10 10. 8% 1. 8% 0 Age ECOG 0/1 ECOG 2 -4 Child A Child B Child C

Cumulative Survival Figure 5. Median survival of patients assigned to curative treatment by BCLC and HKLC staging systems 0 5 10 15 20 Survival Time (Years) 25 30

Cumulative Survival Figure 6. Median survival of patients who received the assigned curative treatment according to the BCLC and HKLC staging systems 0 5 10 15 20 Survival Time (Years) 25 30

Table 1. Baseline characteristics Variable All Patients (n = 1, 270) Age in years, median (range) 63 (13 to 94) Male, n (%) 1046 (82. 4) Ethnicity Chinese 1135 (89. 4) Malay 90 (7. 1) Indian 36 (2. 8) Others 9 (0. 7) Aetiology Hepatitis B 953 (75. 0) Hepatitis C 91 (7. 2) Hepatitis B and C co-infection 48 (3. 8) Others 178 (14. 0) Child-Pugh class A: B: C 641 (50. 5): 452 (35. 6): 177 (13. 9)