Autoantibodies against AT 1 Receptor Contribute to Vascular
Autoantibodies against AT 1 Receptor Contribute to Vascular Aging and Endothelial Cell Senescence Meili Wang, Xiaochen Yin, Suli Zhang, Chenfeng Mao, Ning Cao, Xiaochun Yang, Jingwei Bian, Weiwei Hao, Qian Fan, Huirong Liu 1 Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China. 2 Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Disease, Capital Medical University, Beijing, China. 3 Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China. 4 Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China. 5 Beijing Anzhen Hospital, Capital Medical University, Beijing, China. Figure 4. Changes in arterial morphology after immunization. A) Microscopic images of the HE-stained aortic sections. Scale bar = 400 &#x 003 BC; m. There was no significant difference in arterial wall thickening at 8 weeks, but it increased significantly after 12 -week immunization. B) Quantitative analysis of wall thickness of thoracic aortas at 8 and 12 weeks after immunization. C) Representative images of immunohistochemical staining showing DOI: 10. 14336/AD. 2018. 0919 p 53, p 21 and p 16 INK 4 a in the rat aorta of the indicated groups. Scale bar = 400 (small views) and 40 &#x 003 BC; m (enlarged views). Data were expressed as mean &#x 000 B 1; SEM. n = 6 -8 rats for each group, &#x 0002 A; p &#x 0003 C; 0. 05.
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