ATM mutation rather than BIRC 3 deletion andor

ATM mutation rather than BIRC 3 deletion and/or mutation predicts reduced survival in 11 q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL 4 trial by Matthew J. J. Rose-Zerilli, Jade Forster, Helen Parker, Anton Parker, Ana E. Rodríguez, Tracy Chaplin, Anne Gardiner, Andrew J. Steele, Andrew Collins, Bryan D. Young, Anna Skowronska, Daniel Catovsky, Tatjana Stankovic, David G. Oscier, and Jonathan C. Strefford haematol Volume 99(4): 736 -742 March 31, 2014 © 2014 by Ferrata Storti Foundation

Cohort characteristics. Matthew J. J. Rose-Zerilli et al. Haematologica 2014; 99: 736742 © 2014

Chromosome 11 architecture, 11 q 23 minimally deleted region and BIRC 3 deletion and/or mutation in 11 q-deleted CLL [In color] (A) Left to right: Genomic location in Mb from the telomere of 11 p (top), through the centromere to the telomere of 11 q (bottom); an. . . Matthew J. J. Rose-Zerilli et al. Haematologica 2014; 99: 736742 © 2014 by Ferrata Storti Foundation

Survival models of TP 53, ATM and BIRC 3 disruption in CLL 4 cases.

Overall and progression-free survival in CLL 4 cases (A) and (B) show CLL 4 overall and progression-free survival, respectively; for cases sub-grouped by TP 53 deletion/SNV (dashed black line), BIRC 3 deletion and/or mutation (black line), 11 q deletion without. . . Matthew J. J. Rose-Zerilli et al. Haematologica 2014; 99: 736742 © 2014 by Ferrata Storti Foundation