Assessment of dysplastic hematopoiesis lessons from healthy bone

Assessment of dysplastic hematopoiesis: lessons from healthy bone marrow donors by Stefani Parmentier, Johannes Schetelig, Kerstin Lorenz, Michael Kramer, Robin Ireland, Ulrich Schuler, Rainer Ordemann, Gabi Rall, Markus Schaich, Martin Bornhäuser, Gerhard Ehninger, and Frank Kroschinsky haematol Volume 97(5): 723 -730 May 3, 2012 © 2012 by Ferrata Storti Foundation

Donors’ characteristics. Stefani Parmentier et al. Haematologica 2012; 97: 723 -730 © 2012 by Ferrata Storti Foundation

Morphological manifestations of dysplasia evaluated in the donor bone marrow (according to WHO 2008; 100 cells of granulopoiesis and erythropoiesis and 30 megakaryocytes evaluated by each investigator; results averaged). Stefani Parmentier et al. Haematologica 2012; 97: 723 -730 © 2012 by Ferrata Storti Foundation

Dysgranulopoiesis and dyserythropoiesis: hypogranulated neutrophils (A–B). Stefani Parmentier et al. Haematologica 2012; 97: 723 -730 © 2012 by Ferrata Storti Foundation

Dysmegakaryopoiesis: hypolobated megakaryocyte (AB), binucleated micromegakaryocyte (C), multinucleated megakaryocyte. Stefani Parmentier et al. Haematologica 2012; 97: 723 -730 © 2012 by Ferrata Storti Foundation

Dyshematopoiesis and age. Stefani Parmentier et al. Haematologica 2012; 97: 723 -730 © 2012 by Ferrata Storti Foundation

Investigator concordance (threshold for dysplasia 10%). Stefani Parmentier et al. Haematologica 2012; 97: 723 -730 © 2012 by Ferrata Storti Foundation