APX 3330 Promotes Neurorestorative Effects after Stroke in

APX 3330 Promotes Neurorestorative Effects after Stroke in Type One Diabetic Rats Yan Tao, Venkat Poornima, Chopp Michael, Zacharek Alex, Yu Peng, Ning Ruizhuo, Qiao Xiaoxi, Kelley Mark R. , Chen Jieli 1 Gerontology Institute, Neurology, Tianjin Medical University General Hospital, Tianjin Neurological Institute, Key Laboratory of Post-Neurotrauma Neurorepair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China 2 Department of Neurology, Henry Ford hospital, Detroit, MI, USA 3 Department of Physics, Oakland University, Rochester, MI, USA 4 Department of Neurology, First Hospital Harbin, China. 5 Department of Ophthalmology, Henry Ford Hospital, Detroit, MI, USA 6 Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA Figure 1. APX 3330 improves stroke outcome and decreases ischemic burden and BBB permeability in T 1 DM rats. Treatment with APX 3330 significantly improves neurological functional outcome after stroke in T 1 DM rats as indicated by (A) Foot-fault test and (B) modified neurological severity score (m. NSS). APX 3330 treatment also significantly decreases (C) ischemic lesion volume and (D) BBB disruption after stroke in T 1 DM rats. Aging and Disease, 2018, 9(3), 453 -466. DOI: 10. 14336/AD. 2017. 1130