Applications of API Process Simulation Pharmaceutical API Process
- Slides: 19
Applications of API Process Simulation Pharmaceutical API Process Development and Design
Module Structure • Solvent replacement – Compare feed strategies
Solvent replacement Typical example • Reaction carried out in solvent A • Boil-off part of solvent A • Replace with solvent B & carry-out second reaction step Evaporate A Solvent A Add B Solvent A & B Mix Evaporate Mix Repeat Design Issues: How many steps & How much to boil off each step?
Solvent replacement (contd. ) Reaction Product In Methanol Replace Methanol With Ethyl Acetate Required final Methanol mass Fraction ≤ 0. 01 Optimal feed profile?
Solvent replacement (contd. ) Single stage Batch distillation Temperature Profile of bulk Composition Profile of bulk
Example 3: Feed Profiles For Solvent Switching (see handout for detailed process description)
Balance Volumes 1. 2. 3. 4. Bulk liquid Heating fluid Header tank Vapor
Model Variables Transfer rate of solvent Mass transfer coerfficient Transfer area per unit volume Concentration of solvent in bulk phase Partition coefficient Vapor pressure of solvent Antoine equation constants for solvent Temperature of vapor phase
Mass Transfer Equations (Antoine Equation) (UNIFAC Method)
Feed Profile – Fed Batch Volume Vmax Vmin Time
Feed Profile – Put and Take Vmax Volume Vmin Time
Dyno. Chem Model Summary • Components – Activity coefficients calculated using group contribution method (UNIFAC) – new_solvent • MW=60. 096, groups=2 CH 3+1 CH+1 OH – old_solvent • MW=103. 13, groups=2 CH 3+1 CH 3 COO
Dyno. Chem Model Summary • Process definition (statements) – Phase bulk liquid – Phase vapor – Mass transfer vapor with bulk liquid • Vapor pressure calculated using Antoine equation • Activity coefficients calculated using UNIFAC method – Remove off gas from vapor
Dyno. Chem Model Summary • Process definition (statements) – Heat bulk liquid with jacket – Phase header tank – Transfer to bulk liquid from header tank – Calculate feed rate • Control algorithm for different feed strategies
Dyno. Chem Model Summary • Scenarios (initial values and parameters) – Bulk liquid: Initial temperature, old_solvent – – mass, density, specific heat Feed tank: Temperature, new_solvent mass, density, specific heat Jacket: Temperature difference, flow, specific heat, UA Vapor: Pressure Feed profile control algorithm parameters
Simulation Results
Simulation Results
Simulation Results
Simulation Results
- Pharmaceutical simulation and modeling
- Clinical trial iwr
- Oil and gas process simulation software
- Promax process simulation software
- Spdm (simulation process & data management)
- Simulation process
- Flownex software
- Smart process apps
- Tse bse certificate in pharmaceutical
- Toc in pharmaceutical industry
- Importance of quality in pharmaceutical industry
- Pharmaceutical water system training
- Retention samples of finished product
- Reducing and enlarging definition
- Pharmaceutical supply chain initiative psci
- English for pharmacist
- What goes in black pharmaceutical waste containers
- Discuss about physical incompatibility with example
- Pharmaceutical compliance congress
- Definition of pharmaceutical inorganic chemistry