Antithrombin III human Drugbank ID DB 11598 Description

Antithrombin III human Drugbank ID : DB 11598

Description : A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily. Indication : Short-term replacement therapy for prevention or treatment of thromboembolism in selected patients with congenital antithrombin III deficiency at high risk for thromboembolism (i. e. , those undergoing surgical or obstetrical procedures) or those with thromboembolism. Pharmacodynamics : It s the major plasma inhibitor of thrombin. Inactivation of thrombin by AT -III occurs by formation of a covalent bond resulting in an inactive 1: 1 stoichiometric complex between the two, involving an interaction of the active serine of thrombin and an arginine reactive site on AT-III is also capable of inactivating other components of the coagulation cascade including factors IXa, XIa, and XIIa, as well as plasmin.

Mechanism of action : Neutralizes serine proteinases such as thrombin, plasmin, and activated coagulation factors IX, X, XI, and XII; Principally neutralizes thrombin and activated coagulation factor X (Xa); Neutralization of factor Xa prevents thrombin generation (e. g. , decreased formation of prothrombin fragment 1. 2 [F 1 and F 2]); Neutralization of thrombin prevents conversion of fibrinogen to fibrin; lowly and irreversibly complexes stoichiometrically with these coagulation factors; such reactions are rapid in presence of endogenous heparin-like proteoglycans or exogenous heparin; Inhibits thrombus formation.

Brands : Thrombate III Company : GRIFOLS USA, LLC Used for/Prescribed for : Indicated for the treatment of patients with hereditary antithrombin III deficiency in connection with surgical or obstetrical procedures or when they suffer from thromboembolism. Form : kit

Side effects : Dizziness, chest tightness, nausea, foul taste, chills, cramps, shortness of breath, chest pain, film over eye, lightheadedness, bowel fullness, hives, fever, oozing, hematoma formation.

References : http: //www. drugbank. ca/drugs/DB 11598