Antiobesity Drugs Abstract Assoc Prof Iv Lambev Email

Anti-obesity Drugs (Abstract) Assoc. Prof. Iv. Lambev E-mail: BWI > 35, resp. BW itlambev@mail. bg grater than 30% above ideal, is associated with the development of arterial hypertension, DM, gout, osteoarthrosis, hiatus hernia, hyperlipidemia, sex problems, etc. . . 47% >. .

BMI (BWI) B. M. (kg) height (m)2 Norm: 18. 5– 24. 9

Leptin is a peptide hormone, synthesized and secreted from adipose tissue. It acts on hypothalamus: suppresses appetite, increases body temperature and increases energy costs. It is created recombinant leptin!

Ghrelin is a peptide hormone. It is pro mainly by the fundus of the stomach and epsilon cells of the pancreas. It stimulate hunger. Ghrelin levels increase before m and decrease after meals. It is considere counterpart of the hormone leptin, produ by adipose tissue, which induces saturat when present at higher levels. Ghrelin is a potent stimulator of GH release too.

Orlistat (INN) – Alli : caps. 60 mg – Xenical®: caps. 120 mg It inhibits lipase in the GIT. ADRs: Diarrhoea. Orlistat is reduced BM with 10% after 6 – 8 months.

Metformin: tablets 500 and 1000 mg Sibutramine Its active metabolites inhibit the reuptake of 5 -HT, NA and DA in CNS. Sibutramine can cause hypertension, tachycardia, insomnia, cardiovascular incidents. It is out of date and not use. Rimonabant It is a selective inhibitor of the canabinoid CB 1 -receptors. ADRs: Depression. Rimonabant is out of date and not use.

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