antihypertensive agents ACE inhibitors 1252022 1 1252022 3

antihypertensive agents ACE inhibitors 1/25/2022 1

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Механизъм на действие angiotensinogenase Renin Release --- Angiotensinogen --- Angiotensin I ACE --- Angiotensin II --- Angiotensine III --- Inactive Products 1/25/2022 4

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2 Bradykinin --- Prostaglandin Release --- ACE Vasodilatation Inactive Products 1/25/2022 6

1981 г Captopril (S)-(3 -меркапто-2 -метил-1 -оксопропил)-L-пролин (2 S)-1 -[(2 S)-2 -метил-3 -сулфанилпропаноил] пиролидин-2 -карбоксилова киселина Ph Eur (2 S)-1 -[(2 S)-2 -Methyl-3 -sulphanylpropanoyl]pyrrolidine-2 -carboxylic acid 1/25/2022 Angiotensin-converting enzyme inhibitor 7

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VASOTEC * I. V. (Enalaprilat) is a sterile aqueous solution for intravenous administration. Enalaprilat is an angiotensin converting enzyme inhibitor. It is chemically described as (S)-1 -[N-(1 -carboxy-3 -phenylpropyl)L-alanyl]-L-proline dihydrate. Its empirical formula is C 18 H 24 N 2 O 5 • 2 H 2 O. Enalaprilat is a white to off-white, crystalline powder with a molecular weight of 384. 43. It is sparingly soluble in methanol and slightly soluble in water. Each milliliter of VASOTEC I. V. contains 1. 25 mg enalaprilat (anhydrous equivalent); sodium chloride to adjust tonicity; sodium hydroxide to adjust p. H; water for injection, q. s. ; with benzyl alcohol, 9 mg, added as a preservative 1/25/2022 13

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Perindopril Erbumine Ph Eur 2 -Methylpropan-2 -amine (2 S, 3 a. S, 7 a. S)-1 -[(2 S)-2[[(1 S)-1 -(ethoxycarbonyl)butyl]amino]propanoyl]octahydro 1 H-indole-2 -carboxylate 1/25/2022 19

Представители Trandolapril Ph Eur (2 S, 3 a. R, 7 a. S)-1 -[(2 S)-2 -[[(1 S)-1 -(Ethoxycarbonyl)-3 phenylpropyl]amino]propanoyl]octahydro-1 H-indole-2 - carboxylic acid 1/25/2022 20

Представители Cilazapril Ph Eur (1 S, 9 S)-9 -[[(1 S)-1 -(ethoxycarbonyl)-3 -phenylpropyl]amino]10 -oxooctahydro-6 H-pyridazino[1, 2 -a] [1, 2]diazepine-1 -carboxylic acid 1/25/2022 21

Представители Spirapril Hydrochloride Monohydrate Ph Eur (8 S)-7 -[(2 S)-2 -[[(1 S)-1 -(Ethoxycarbonyl)-3 -phenylpropyl]amino]propanoyl]1, 4 -dithia-7 -azaspiro[4. 4]nonane-8 -carboxylic acid hydrochloride monohydrate 1/25/2022 22

Ramipril (2 S, 3 a. S, 6 a. S)-1 -[(S)-2 -[[(S)1 -(етоксикарбонил)3 - фенилпропил]aмино]пропаноил]oктахидроциклопента[b]пирол 2 -карбоксилова киселина Ph Eur (2 S, 3 a. S, 6 a. S)-1 -[(S)-2 -[[(S)-1 -(ethoxycarbonyl)-3 phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole -2 -carboxylic acid 1/25/2022 23

Представители angiotensin II receptor (type AT 1) antagonist Losartan Non-peptide angiotensin II receptor antagonist 2 -бутил-4 -хлоро-1 -[[2`-(1 Н-тетразол-5 -ил)[1, 1`-бифенил]-4 -ил] метил]-1 Н-имидазол-5 -метанол 1/25/2022 25

Losartan potassium 1/25/2022 26

Представители Valsartan Nonpeptide angiotensin II AT 1 – receptorantagonist N-(1 -оксопентил)-N-[[2`-(1 Н-тетразол-5 -ил)[1, 1`-бифенил]4 -ил]метил]-L-валин 1/25/2022 27

Eprosartan non-tetrazole angiotensin II receptor (AT 1) antagonist. Prototype of the imidazoleacrylic acid angiotensin II receptor antagonists (Е)-alfa-[[2 -бутил-1 -[(4 -карбоксифенил)метил]1 Н-имидазол-5 -ил]метилен]-2 тиофенпропанова киселина монометансулфонат 1/25/2022 29