Antidepressants for nonspecific low back pain Urquhart et
Antidepressants for non-specific low back pain Urquhart et al (2008) Trusted evidence. Informed decisions. Better health. This document is licensed under a Creative Commons Attribution Non. Commercial. No. Derivatives 4. 0 International License: http: //creativecommons. org/licenses/by-nc-nd/4. 0/ That means this document can be used and shared as long as IWH is credited as the source, the contents are not modified, and the contents are used for non-commercial purposes. If you wish to modify and/or use the contents for commercial purposes, please contact ip@iwh. on. ca.
Antidepressants for non-specific low back pain Urquhart et al (2008) Overview of the study Objectives • To determine whether antidepressants are more effective than placebo for the treatment of non-specific low-back pain. Methods • Evidence current up to 11 November 2008 • Participants: Adults with non-specific low-back pain • Interventions: Any type of antidepressant * • Outcomes: o Primary: Pain intensity, overall improvement, functional status, return-towork and depression o Secondary: Physiological outcomes, generic functional status * i. e. tricyclic and heterocyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), mono-amine oxidase (MAO) inhibitors and 'atypical' antidepressants
Antidepressants for non-specific low back pain Urquhart et al (2008) Results & Conclusions • 10 trials (total number of participants not available) Quality of evidence Interventions Evidence Antidepressants Chronic LBP: no clear evidence of being better than placebo in reducing depression Not available* Chronic LBP: conflicting evidence on reducing pain intensity compared to placebo Not available* Ø Adverse events: some reported but not serious Ø There is no clear evidence that antidepressants are more effective than placebo in the management of patients with chronic low-back pain * GRADE was not used to assess the quality of the evidence
- Slides: 3