Anatomy Physiology and Disorders of the Hearing Perry
- Slides: 106
Anatomy Physiology and Disorders of the Hearing Perry C. Hanavan, Au. D. Audiologist
Major Divisions of the Ear Peripheral Mechanism VIII Outer Middle Inner Cranial Ear Ear Nerve Central Mechanism Brain
Question What is the purpose of the pinna? A. Cosmetics B. Sound collector C. Same side localization D. A and B E. A, B and C
Outer Ear Virtual Tour of the Ear Pinna Preauricular Tags Preauricular Pits EAM External Auditory Meatus Cerumen Q-tips Function Microtia EAM resonance Anotia Atresia
Pinna
Question Another name for pinna? A. External auditory meatus B. External auditory canal C. Ear lobe D. Auricle E. None of the above
Function of Outer Ear • • • Collect sound Localization Resonator Protection Sensitive (earlobe) Other?
Pinna • The visible portion that is commonly referred to as "the ear" • Helps localize sound sources • Directs sound into the ear • Each individual's pinna creates a distinctive imprint on the acoustic wave traveling into the auditory canal
External Auditory Meatus • Extends from the pinna to the tympanic membrane – About 26 millimeters (mm) in length and 7 mm in diameter in adult ear. – Size and shape vary among individuals. • Protects the eardrum • Resonator – Provides about 10 decibels (d. B) of gain to the eardrum at around 3, 300 Hertz (Hz). • The net effect of the head, pinna, and ear canal is that sounds in the 2, 000 to 4, 000 Hz region are amplified by 10 to 15 d. B. – Sensitivity to sounds greatest in this frequency region – Noises in this range are the most hazardous to hearing
Outer Ear Resonance • Influence of pinna (p) • Influence of ear canal (m) • Combine influence (t) • At 3000 Hz, the final amplification (t) is 20 d. B
Question Cerumen should be routinely removed from the ear canal? A. True B. False
Cerumen • The purpose of wax: – Repel water – Trap dust, sand particles, microorganisms, and other debris – Moisturize epithelium in ear canal – Odor discourages insects – Antibiotic, antiviral, antifungal properties – Cleanse ear canal
Embryological Development • External Ear Development
Disorders of the Outer Ear Accessory auricle Additional pinna or auricular tissue Anotia Congenital absence of pinna Cleft pinna Congenital fissure of the pinna Coloboma lobuli Congenital fissure of the earlobe Macrotia Congenital excessive enlargement of the auricle Microtia Congenital small pinna Melotia Congenital displacement of the pinna Low-set-ears Congenitally displaced pinna Polyotia Additional pinna on one or both sides Preauricular tags Small appendage anterior to pinna Scroll ear Rim (helix) of pinna is rolled forward and inward
Outer Ear Hearing Disorders • Outer ear • CHARGE • Down Syndrome – Ears small and low set • Fetal Alcohol Syndrome – Deformed ears • Di. George syndrome – Low set ears
Grow Ear?
External Ear Care Hazardous to health: • Ear candling • Swabs • Foreign objects
Time of Onset Congenital Present at birth Acquired Occurring after birth Adventitious Occurring after birth Acute Sudden onset or short duration Chronic Long duration Sudden Rapid onset Gradual Occurring slowly Temporary Limited duration Permanent Irreversible Progressive Increasing in degree over time Fluctuating Increasing and decreasing in degree of loss
Middle Ear The function of the middle ear is to? A. Cause middle ear infections in young children B. Amplify sounds C. Interpret sounds D. Analyze sounds E. None of the above
Middle Ear The Eustachian tube is a part of the middle ear? A. No, it is a part of the inner ear B. No, it isn’t part of the hearing mechanism C. Yes D. I don’t know
Middle Ear Which is not true? A. There are two middle ear muscles B. There are three ossicles C. There are three layers of tympanic membrane tissue D. The acoustic reflex occurs from soft sounds E. The stapes is the smallest bone in the human body
Middle Ear Virtual Tour of the Ear Middle Ear Cavity Tympanic Membrane Ossicles Middle Ear Muscles Eustachian Tube Mastoid Ossicles Middle Ear Muscles Mastoid Eustachian Tube Function Amplifier Cholesteatoma Temporal bone fractures Otitis Media PE tubes Otosclerosis
Function of Middle Ear • Conduction – Conduct sound from the outer ear to the inner ear • Protection – Creates a barrier that protects the middle and inner areas from foreign objects – Middle ear muscles may provide protection from loud sounds • Transducer – Converts acoustic energy to mechanical energy – Converts mechanical energy to hydraulic energy • Amplifier – Transformer action of the middle ear – only about 1/1000 of the acoustic energy in air would be transmitted to the inner-ear fluids (about 30 d. B hearing loss)
The middle ear: A. Converts acoustic energy to hydraulic B. Converts hydraulic energy to mechanical C. Converts acoustic energy to mechanical D. Converts acoustic energy to electrical E. Converts mechanical to electrical
Middle Ear Tympanum: Timpani, or kettledrums, are musical instruments in the percussion family. A type of drum, they consist of a skin called a head stretched over a large bowl commonly made of copper. They are played by striking the head with a special drum stick called a timpani stick. Timpani evolved from military drums to become a staple of the classical orchestra in the 17 th century. Today, they are used in many types of musical ensembles including classical orchestra
Tympanic Membrane • The eardrum separates the outer ear from the middle ear • Creates a barrier that protects the middle and inner areas from foreign objects • Cone-shaped in appearance – about 17. 5 mm in diameter • The eardrum vibrates in response to sound pressure waves. • The membrane movement is incredibly small – as little as one-billionth of a centimeter
The pars tensa portion of the TM: A. Consists of 2 layers of tissue B. Consists of 4 layers of tissue C. Consists of 1 layer of tissue D. Consists of 3 layers of tissue E. Consists of 5 layers of tissue
Eustachian Tube • The eustachian tube connects the front wall of the middle ear with the nasopharynx • The eustachian tube also operates like a valve, which opens during swallowing and yawning – This equalizes the pressure on either side of the eardrum, which is necessary for optimal hearing. – Without this function, a difference between the static pressure in the middle ear and the outside pressure may develop, causing the eardrum to displace inward or outward • This reduces the efficiency of the middle ear and less acoustic energy will be transmitted to the inner ear.
The Eustachian tube: A. Opens when one yawns B. Opens when one smiles C. Opens when one blinks D. It is always open E. Never opens
Ossicles • Malleus (hammer) • Incus (anvil) • Stapes (stirrup) smallest bone of the body
The middle ear amplifies sound: A. About 15 d. B B. About 25 d. B C. About 35 d. B D. About 20 d. B E. About 40 d. B
Transformer/Amplifier • Transform the vibrating motion of the eardrum into motion of the stapes. • The middle ear enhances the transfer of acoustical energy in two ways: – The area of the eardrum is about 17 times larger than the oval window • The effective pressure (force per unit area) is increased by this amount. – The ossicles produce a lever action that further amplifies the pressure • Without the transformer action of middle ear, about 1/1000 of acoustic energy in air transmitted to inner-ear fluids (about 30 d. B loss). • Malleus and incus vibrate together, transmitting the sound waves from the eardrum to the footplate of the stapes (this pushes the oval window in and out)(mechanical energy)
Transformer/Amplifier • Area ratio – Thumbtack • Lever – crowbar
Which provides the most amplification in the middle ear? A. The lever hypothesis B. The area/ratio hypothesis C. The Hanavan principle D. I don’t know E. None of the above
Middle Ear Muscles • Tensor tympani – Attached to malleus – Innervated by V, trigeminal nerve • Stapedius – Attached to stapes – Innervated by VII, facial nerve • Middle Ear Muscle Function: – Help maintain ossicles in proper position – Protect inner ear from excessive sound levels • When ear exposed to sound levels above 70 d. B, the muscles contract, decreasing amount of energy transferred to inner ear – This protective reflex termed "acoustic reflex"
The VII cranial nerve innervates: A. Tensor tympani muscle B. Incus C. Stapedial muscle D. Malleus E. Stapes
The tensor tympani: A. Innervated by the facial nerve B. Innervated by the trigeminal nerve C. Innervated by the VII cranial nerve D. Innervated by the VIII cranial nerve E. Innervated by the VI cranial nerve
Ligaments of Middle Ear • Function – restrict and confine the effect of ossicles to act as a lever – restrict movements to reduce the chance of damage to the inner ear – prevents distortion to sound
Mastoid
Mastitis A. Inflammation of the mastoid B. Inflammation of the breast C. Cancer of the mast cells D. A and B E. B and C
Question The correct order of the ossicles from the TM to inner ear is? A. Anvil, hammer, stapes B. Hammer, incus, anvil C. Hammer, anvil, stapes D. Stapes, anvil, hammer E. Malleus, stapes, incus
Development of Middle Ear • Middle Ear Development
Middle Ear Disorders • Middle Ear disorders – – – – – Acute otitis media Otosclerosis Disarticulation Mastoiditis Tympanosclerosis OME TM Perforation TM Retraction Cholesteatoma • Down Syndrome • Treacher Collins Syndrome • BOR Syndrome
OM/OME
Cholesteatoma
Otosclerosis • Develops most frequently between ages of 10 and 30. • About 10– 15% of patients have unilateral loss. • Affects women more frequently than men by a ratio of 2: 1. • Pregnancy once thought to be a risk factor for the development and / or worsening of otosclerosis…recent studies have disputed this. • May progress to nerve deafness called cochlear otosclerosis.
Question The Amy Tan syndrome is: A. Down syndrome B. BOR syndrome C. Treacher Collins syndrome D. Measles syndrome E. Waardenburg syndrome
Question The function of the inner ear: A. Balance B. Hearing C. Touch D. All the above E. A and B
Inner Ear Virtual Tour of the Ear Vestibular Auditory semicircular canals utricle and saccule Cochlear traveling wave Vestibular traveling wave pathologies
Function of Inner Ear • Convert mechanical sound waves to neural impulses that can be recognized by the brain for: – Hearing – Balance
Balance • Linear motion • Rotary motion
Question Which is true about the inner ear and balance? A. The semicircular canals detect linear motion B. The utricle and saccule detect linear motion C. The cochlea detects linear motion D. The utricle and saccule detect rotary motion
Cochlea • The cochlea resembles a snail shell and spirals for about 2 3/4 turns around a bony column • Within the cochlea are three canals: – Scala Vestibuli – Scala Tympani – Scala Media
Question The channel that houses the organ of Corti: A. Scala tympani B. Scala media C. Scala vestibuli D. Semicircular canals E. B and D
Anatomy of the adult mammalian cochlea Barald, K. F. et al. Development 2004; 131: 4119 -4130
Organ of Corti
Organ of Corti
Organ of Corti
OHC vs. IHC Function
OHC Motility Models
Afferent Neural Innervations
Hair Cells • Outer Hair Cells • Inner Hair Cells • OHC movie
OCH Cilia Theory: Tip-links <<<IHC OHC >>>
OHC Cilia: Tip-links
Tip Link Protiens
Stereocilia move sideways and lengthen (Oct 2, 2012)
Flexoelectric Effect • Quiet sounds are magnified by bundles of tiny, hair-like tubes atop "hair cells" in the ear (stereocilia: when the tubes dance back and forth, they act as "flexoelectric motors" that amplify sound mechanically. • "It's like a car's power steering system. " – " You turn the wheel and mechanical power is added. Here, the incoming sound is like your hand turning the wheel, but to drive, you need to add power to it. These hair bundles add power to the sound. If you did not have this mechanism, you would need a powerful hearing aid. “ – http: //www. medicalnewstoday. com/articles/147081. php
OHC Somatic Motility
Question Which cells are motile? A. Brain cells B. Inner hair cells C. Outer hair cells D. B and C E. None of the above
OHC—With and Without Prestin • No other cells except OHC • Prestin is the motor protein of mammalian OHCs. • It is highly expressed in OHC, and is not expressed in nonmotile IHC.
OHC—With and Without Prestin About 55 d. B difference OHC in Prestin Knockout Mouse
Traveling Waves • • Traveling wave Basilar membrane Traveling Wave info Cochlear Traveling Wave
Question High frequencies stimulate this part of inner ear: A. Apical portion of inner ear B. Basilar portion of inner ear C. Utricle D. Saccule E. Semicircular canals
Inner Ear Etiologies • Genetic – Connexin 26 • Excessive Noise • Head Trauma • Metabolic – Diabetes, kidney disfunction, thyroid dysfunction • Ototoxic – Gentamiacin, cisplatin, etc. • Disease
Connexin 26
Noise Trauma
Question Persons with diabetes are at greater risk for hearing loss…this would be? A. Metabolic B. Noise related C. Ototoxic D. Genetic E. Acoustic trauma related
Question Persons with Connexin 26 are at greater risk for hearing loss…this would be: A. Metabolic B. Noise related C. Ototoxic D. Genetic E. Acoustic trauma related
Developmental • Inner Ear Embryological Development
Question The hearing nerve is located in: A. Eustachian tube B. External auditory meatus C. Internal auditory meatus D. Organ of Corti E. Tympani
Question The auditory nerve is which cranial nerve: A. VI B. VII C. VIII D. V E. X
VIII Cranial Nerve Virtual Tour of the Ear Auditory Branch Vestibular Branch Spiral ganglion Acoustic Tumors
Standard ABR Cross-section of Internal Auditory Canal Sup. Vest Nerve Facial Nerve HIGHFREQUENCY FIBERS Acoustic Nerve Large Tumor Abnormal Standard ABR TUMOR The wave V latency used in the standard ABR IT 5 and I-V delay measures is dominated by neural activity from the high-frequency regions of the cochlea. Thus, unless the tumor affects these high-frequency fibers sufficiently, standard ABR latencies will be normal. Inf. Vest Nerve Small Tumor Abnormal Standard ABR Small Tumor Normal Standard ABR
IAM
VIII Cranial Nerve
Spiral Ganglion
Question The Auditory Nerve is: A. V Cranial Nerve B. VI Cranial Nerve C. VII Cranial Nerve D. VIII Cranial Nerve E. IX Cranial Nerve
Acoustic Neuroma • Tumor
Neurofibromatosis (NF 2) • Bilateral acoustic neuromas (tumors of the vestibulocochlear nerve or cranial nerve VIII also known as schwannoma) develop, often leading to hearing loss • Multiple inherited schwannomas and meningiomas • Non-malignant brain tumors (benign)
Acoustic Neuroma
Question Another term for acoustic tumor: A. VII cranial nerve tumor B. Vestibular schwannoma C. Facial nerve tumor D. Ear schwannoma
Stem Cells Restore Hearing Human stem cells regenerate auditory nerve cells in gerbils
Central Auditory Mechanism Virtual Tour of the Ear Auditory Path
Central Auditory Path
Auditory Pathway - CNS
Tonotopic
Etiologies • Central auditory processing disorders – Brainstem – Cerebrum – Corpus callosum • Learning disorders • Vascular – Stoke • Head trauma • Tumors
Nonorganic Hearing Loss • Sometimes referred to as functional, feigning, etc. • No physical evidence of hearing loss • Conscious and unconscious • Adults: medical/legal reasons • Children: attention, psychological, reward, etc.
Development of the otocyst Barald, K. F. et al. Development 2004; 131: 4119 -4130
Inductive interactions that regulate otocyst induction and ventral patterning Barald, K. F. et al. Development 2004; 131: 4119 -4130
Development of the cochlear duct and organ of Corti Barald, K. F. et al. Development 2004; 131: 4119 -4130
Effects of modulating gene expression on development of the organ of Corti (OC) Barald, K. F. et al. Development 2004; 131: 4119 -4130
Generation of stereociliary bundle orientation Barald, K. F. et al. Development 2004; 131: 4119 -4130
Six 1 expression during inner ear development Zheng, W. et al. Development 2003; 130: 3989 -4000
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