An abnormal bone marrow microenvironment contributes to hematopoietic

An abnormal bone marrow microenvironment contributes to hematopoietic dysfunction in Fanconi anemia by Yuan Zhou, Yongzheng He, Wen Xing, Peng Zhang, Hui Shi, Shi Chen, Jun Shi, Jie Bai, Steven D. Rhodes, Fengqui Zhang, Jin Yuan, Xianlin Yang, Xiaofan Zhu, Yan Li, Helmut Hanenberg, Mingjiang Xu, Kent A. Robertson, Weiping Yuan, Grzegorz Nalepa, Tao Cheng, D. Wade Clapp, and Feng-Chun Yang haematol Volume 102(6): 1017 -1027 May 31, 2017 © 2017 by Ferrata Storti Foundation

Poor survival and hematopoietic defects in double knockout mice. Yuan Zhou et al. Haematologica 2017; 102: 1017 -1027 © 2017 by Ferrata Storti Foundation

Double knockout mice had retarded growth and impaired bone mineralization. Yuan Zhou et al. Haematologica 2017; 102: 1017 -1027 © 2017 by Ferrata Storti Foundation

In vitro analysis of mesenchymal stem progenitor cell frequency and osteoblast differentiation. Yuan Zhou et al. Haematologica 2017; 102: 1017 -1027 © 2017 by Ferrata Storti Foundation

Co-culture of double knockout mesenchymal stem/progenitor cells with hematopoietic stem/progenitor cells showed the decreased hematopoietic supportive activity. Yuan Zhou et al. Haematologica 2017; 102: 1017 -1027 © 2017 by Ferrata Storti Foundation

Impaired cellular functions of Fanconi anemia patient-derived mesenchymal stem/progenitor cells. Yuan Zhou et al. Haematologica 2017; 102: 1017 -1027 © 2017 by Ferrata Storti Foundation