AMPKAMPactivated protein kinase Page 845 Page 845 Thr
- Slides: 33
AMPK(AMP-activated protein kinase) Page 845
Page 845 Thr 172 Bateman doman 1 Bateman doman 2 CBS: cystathionine-b-synthase
AMPK Controls Whole-Body Energy Homeostasis Page 846 Metformin
Page 848
Page 848
During Prolonged Fasting or Starvation (in Brain) Page 849
Page 849
In Muscle Page 849 & 850
Page 850
Glucose and Lactate Are Transported in the Cori Cycle Page 850
Fasting or Excessive Activity in Muscle Page 851 (The Glucose-Alanine Cycle Transfers Alanine to the Liver)
Page 852 Thermogenin(uncoupling protein 1)
Page 852
Liver Glucokinase vs. Hexokinase Page 852
Metabolic Pathways for Glucose 6 -phosphate in the Liver Page 852
Metabolism of Fatty Acids in the Liver Page 852
Metabolism of Amino Acids in the Liver Page 853
The Hormones That Control Eating Behavior Come from Many Different Tissues Page 854 Orexic(appetite-stimulating) vs anorexic(appetite-suppressing)
Ghrelin Short-Term Eating Behavior Is Influenced by Ghrelin and PYY 3 -36 Page 937 (Lehn)
Page 931 (Lehn)
Obesity Caused by Defective Leptin Production Page 931 (Lehn) *OB gene (leptin) & DB gene (diabetic; leptin receptor) BMI(body mass index)=weight in kg/ (height in m)2
Page 933 (Lehn)
Insulin and Leptin Are Long-Term Regulators of Eating Behavior Page 934 (Lehn)
Page 934 (Lehn) *AMP-dependent protein kinase (AMPK)
Page 935 (Lehn)
Mode of action of PPARs (Peroxisome Proliferator-activated Receptors) Page 936 (Lehn) RXR: retinoid X receptor
Metabolic integration by PPARs Page 936 (Lehn)
Sirt 1 Is a Key Regulator in Caloric Restriction (NAD+-dependent protein deacetylase) Deacetylated -peptide Page 857
Sirt 1 Is a Key Regulator in Caloric Restriction Page 857 Sir 2(silent information regulator 2) PGC-1(peroxisome proliferator-activator receptor- g coactivor-1)
Resveratrol, a Compound Found in Red Wine, is a Potent Activator of Sirtuin Activity Page 857
“Lipid Burden” Hypothesis for the Development of Type 2 Diabetes Mellitus Page 939 (Lehn)
Page 939 (Lehn)