Aminobisphonates prevent the inhibitory effects exerted by lymph

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Aminobisphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor Vδ

Aminobisphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor Vδ 2 T lymphocytes in non-Hodgkin lymphomas by Alessandra Musso, Silvia Catellani, Paolo Canevali, Sara Tavella, Roberta Venè, Silvia Boero, Ivana Pierri, Marco Gobbi, Annalisa Kunkl, Jean-Louis Ravetti, Maria Raffaella Zocchi, and Alessandro Poggi haematol Volume 99(1): 131 -139 January 14, 2014 © 2014 by Ferrata Storti Foundation

N-BPs prevent the inhibition of NKG 2 D-mediated lymphoid cell killing and NKG 2

N-BPs prevent the inhibition of NKG 2 D-mediated lymphoid cell killing and NKG 2 D downregulation induced by LNMSC on Vδ 2 T cells. Alessandra Musso et al. Haematologica 2014; 99: 131 -139 © 2014 by Ferrata Storti Foundation

Effects of N-BPs on TGFβ or IL 15 expression in LNMSC and IL 10,

Effects of N-BPs on TGFβ or IL 15 expression in LNMSC and IL 10, TNFα, IFNγ production in Vδ 2 T cells. Alessandra Musso et al. Haematologica 2014; 99: 131 -139 © 2014 by Ferrata Storti Foundation

N-BPs-treated LNMSC drive Vδ 2 T lymphocyte to effector memory T cells. Alessandra Musso

N-BPs-treated LNMSC drive Vδ 2 T lymphocyte to effector memory T cells. Alessandra Musso et al. Haematologica 2014; 99: 131 -139 © 2014 by Ferrata Storti Foundation

Vδ 2 T-lymphocyte phenotype in NHL in situ. Alessandra Musso et al. Haematologica 2014;

Vδ 2 T-lymphocyte phenotype in NHL in situ. Alessandra Musso et al. Haematologica 2014; 99: 131 -139 © 2014 by Ferrata Storti Foundation

Expression of genes characterizing the different Th subsets in NHL lymph nodes. Alessandra Musso

Expression of genes characterizing the different Th subsets in NHL lymph nodes. Alessandra Musso et al. Haematologica 2014; 99: 131 -139 © 2014 by Ferrata Storti Foundation