AMIDES WHAT ARE AMIDES MADE OF Amides are

AMIDES

WHAT ARE AMIDES MADE OF? Amides are produced when a carboxylic acid reacts with an amine or ammonia. This process is called amidation. opentextbc. ca

FUNCTION OF AMIDES • “Amides are critical in the structures and functions of proteins and enzymes. The linkages of amides between these two amino acids are called peptide bonds” • Peptide bonds are extremely important because they are what allow living organisms to create long chains of amino acids. organicchemexplained. com, biologydictionary. net

AMIDES HAVE MULTIPLE LEVELS • Amides have a primary, a secondary, and a tertiary structure. § Primary (1 o amide): NH 2 is directly bonded to the C=O (carbonyl group). chem. ucla. edu

AMIDES HAVE MULTIPLE LEVELS § Secondary (2 o amide): Nitrogen is directly bonded to the C=O plus another carbon. chem. ucla. edu

AMIDES HAVE MULTIPLE LEVELS • Tertiary (3 o amide): Nitrogen is directly bonded to the C=O plus two other carbons. chem. ucla. edu

MOLECULAR FORMULA OF A SIMPLE AMIDE CO-NH 2 chem. ucla. edu

COMPOUNDS AMIDES ARE FOUND IN Important plastics: Nylons, Aramid, Twaron, and Kevlar thoughtco. com Medicines/Drugs: Penicillin, anesthetics, LSD, and many, many others go. drugbank. com Caffeine sciencedirect. com

CHARACTERISTICS OF AMIDES NEUTRAL IN WATER HIGH BOILING POINT HIGH MELTING POINT chem. libretexts. org POLAR MOST ARE SOLID AT ROOM TEMPERATURE

COOL AMIDE CONCEPTS • Highly stable and adopt three-dimensional structures • • Weak bases and do not have clearly defined acid-base properties in water • • nbci. nlm. nih. gov sciencedirect. com Unlike other carbonyl-containing compounds (compounds containing a carbon-oxygen double bond), amides are non-electrophilic • Basically doesn't accept electrons • study. com