Albendazole Donation Programme Update Tijana Williams GSK Supply

Albendazole Donation Programme Update Tijana Williams

GSK Supply Chain Up to 600 million Albendazole tablets each year to WHO until LF is eliminated as a public health problem Up to 400 million Albendazole tablets each year to WHO through 2020 for de-worming of school age children India Supply Global Supply 3 rd Party API Manufacture Se. Quent, India 3 rd Party API Manufacture Uquifa, Mexico Secondary Manufacture Nashik, India Secondary Manufacture Cape Town 400 Million (m) Government Warehouse India Tablets /year 600 Million (m) Tablets /year Government Warehouses Global

Total Number of Tablets Donated/Year for LF & STH (m) 900. 0 LF Total 800. 0 STH Total 770. 4 680. 5 700. 0 647. 9 609. 9 600. 0 643. 6 630. 7 601. 9 585. 7 588. 9 Axis Title 500. 0 423. 5 384. 5 400. 0 287. 3 300. 0 258. 3 193. 1 200. 0 136. 0 100. 0 33. 9 44. 8 0. 0 359. 1 0. 5 0. 0 66. 1 0. 0 181. 6 154. 9 121. 0 114. 5 93. 3 82. 9 0. 0 242. 0 123. 7 78. 8 0. 0 0. 0 16. 8 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019

Cumulative Number of Tablets Donated/Year (m) 10000 9, 156 9000 8, 718 7, 875 8000 6, 980 7000 5, 965 6000 5, 063 5000 4, 201 4000 3, 439 3000 2, 729 2, 126 2000 1, 517 1000 0 1 34 79 145 239 322 458 613 806 1, 093 199920002001200220032004200520062007200820092010201120122013201420152016201720182019

The LF programme has had substantial achievements: § Over 890 m individuals have been treated at least once. § 69 countries implementing MDA, delivering a cumulative total of 7. 1 billion treatments § Current estimates suggest c. 175 m DALYs have been saved since the beginning of the programme. § 15 countries having achieved the validation criteria for elimination of LF as a public health problem § 22 countries no longer requiring MDA nationally § 52 countries reducing infection below target thresholds and no longer requiring MDA in at least 1 district § National programmes targeted 585. 9 million people for treatment during MDA and achieved programme coverage of 79. 4%. § An estimated 133. 1 million school-aged children (5– 14 years of age) were treated during LF MDA. § The number of people requiring interventions for NTDs has been defined as the NTD indicator to monitor progress towards achieving Sustainable Development Goal (SDG) 3. 3. 8 § Prevented or cured more than 97 million cases § Forecasted to avert >US $100 billion in economic loss Data from 2017

The STH strategy has led to substantial achievements: • 500 000 DALYs/year have been estimated to have been averted by control (out of 3. 5 m DALYs estimated) • More than 596 million school age children (SAC) in 105 countries or territories were estimated to require PC. • 7 countries had completely eliminated morbidity due to STH infections of moderate or heavy intensity. – All 7 were countries supplied with albendazole from GSK. • 21 countries have achieved 5 years of MDA rounds and ≥ 75% coverage. • 29 countercries achieved ≥ 75% coverage overall. • Globally, 410. 1 million SAC requiring PC received PC for STH; corresponding to a global coverage of 68. 8%. – Abound 65% of these are treated with GSK donated albendazole – About 84% of treatments to SAC were provided by STH control programmes • Evaluation of STH epidemiology is recommended after more than 5 years of PC. • The number of people requiring interventions for NTDs has been defined as the NTD indicator to monitor progress towards achieving Sustainable Development Goal (SDG) 3. 3. 8 Data from 2017

Global Demand Plan beyond 2020