Aging What is aging is a normal developmental

What is aging? • is a normal developmental factor and a continuous lifelong process

“The theories of aging? ” • Chronological aging • Biological aging • Psychological aging

Aubrey de Grey • English author and biomedical gerontologist. • Chief Science Officer of

SENS Research Foundation • SENS = Strategies for Engineered Negligible Senescence • A US-registered

SRF Education • SRF Education is trying to make the field of regenerative medicine

Aging cause problems • Costs • National • Family members • Suffering • Tragedy

Aubrey de Grey: What if we can end aging? • A car designed for

Damages 1. 2. 3. 4. Junk (inside/outside) Number of cells (too few/many) Mutations Protein

Robust Human Rejuvenation Damage rising with age Method Cell loss, cell atrophy Cell therapy

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Aging？

What is aging? • is a normal developmental factor and a continuous lifelong process that begins at birth and ends in death. • In humans, aging represents the accumulation of changes in a human being over time, encompassing physical, psychological, and social change.

“The theories of aging? ” • Chronological aging • Biological aging • Psychological aging • Social aging

ABOUT THE SPEAKER

Aubrey de Grey • English author and biomedical gerontologist. • Chief Science Officer of the SENS Research Foundation. • He works to identify and promote specific technological approaches to the reversal of various aspects of aging.

SENS Research Foundation • SENS = Strategies for Engineered Negligible Senescence • A US-registered charity that works to develop, promote and enable widespread access to regenerated medicine solution to the disabilities and diseases of aging.

SRF Education • SRF Education is trying to make the field of regenerative medicine comprehensible to everyone. • They offers a number of different options for student research.

Aging cause problems • Costs • National • Family members • Suffering • Tragedy

20 years ago 8. 8 adults ↓ 1 elderly

NOW 5. 6 adults ↓ 1 elderly

10 more years 3. 2 adults ↓ 1 elderly

Aubrey de Grey: What if we can end aging? • A car designed for only 15 years can last for 100 years • Why we cannot? • Human body is a machine

How aging makes us sick?

Metabolism Damage Pathology

Then How?

Damages 1. 2. 3. 4. Junk (inside/outside) Number of cells (too few/many) Mutations Protein crosslinks

Robust Human Rejuvenation Damage rising with age Method Cell loss, cell atrophy Cell therapy Extracellular junk Phagocytosis by immune stimulation Extracellular crosslinks AGE-breaking molecules/enzymes Death-resistant cells Suicide genes, immune stimulation Mitochondrial mutations Allotopic expression of 13 proteins Intracellular junk Transgenic microbial hydrolases Nuclear [epi] mutations (cancer related matters) Telomerase/ALT gene deletion plus periodic stem cell reseeding

Telomerase therapy

Prevention

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