Aggressive large Bcell lymphoma with plasma cell differentiation

Aggressive large B-cell lymphoma with plasma cell differentiation: immunohistochemical characterization of plasmablastic lymphoma and diffuse large B-cell lymphoma with partial plasmablastic phenotype by Santiago Montes-Moreno, Ana-Rosa Gonzalez-Medina, Socorro-María Rodriguez -Pinilla, Lorena Maestre, Lydia Sanchez-Verde, Giovanna Roncador, Manuela Mollejo, Juan F. García, Javier Menarguez, Carlos Montalbán, M. Carmen Ruiz. Marcellan, Eulogio Conde, and Miguel A. Piris haematol Volume 95(8): 1342 -1349 July 31, 2010 © 2010 by Ferrata Storti Foundation

Distinct phenotypic profiles among plasmablastic lymphoma (PBL). Santiago Montes-Moreno et al. Haematologica 2010; 95: 1342 -1349 © 2010 by Ferrata Storti Foundation

Plasmablastic lymphoma and DLBCL show clearly different responses to therapy and survival. Santiago Montes-Moreno et al. Haematologica 2010; 95: 1342 -1349 © 2010 by Ferrata Storti Foundation

Overall (A) and failure free (B) survival curves for DLBCL divided taking into account PRDM 1/BLIMP 1 expression. Santiago Montes-Moreno et al. Haematologica 2010; 95: 1342 -1349 © 2010 by Ferrata Storti Foundation

Phenotypic profile of PBL cases. Santiago Montes-Moreno et al. Haematologica 2010; 95: 1342 -1349 © 2010 by Ferrata Storti Foundation

Use of a panel including PAX 5&CD 20, PRDM 1/BLIMP 1 and XBP 1 s allows a definition of a plasmablastic immunophenotype, which is variably expressed in PBL cases. Santiago Montes-Moreno et al. Haematologica 2010; 95: 1342 -1349 © 2010 by Ferrata Storti Foundation