Agerelated Dysregulation of Inflammation and Innate Immunity Lessons

Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models Aleah L. Brubaker 1 3 4 5 ; Jessica L. Palmer 1 2 3 ; Elizabeth J. Kovacs 1 2 3 4 5 ; 1 The Burn and Shock Trauma Institute, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA ; 2 Department of Surgery, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA ; 3 Immunology and Aging Program, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA ; 4 Program of Cell Biology, Neurobiology, and Anatomy, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA ; 5 Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA ; Figure 2 Impact of age on DC-priming of the adaptive immune response DCs are critical in the crosstalk between the innate and adaptive immune response, helping to generate and regulate CD 4 + T cell, CD 8 + T cell, Treg and Th 17 immune reactions. In response to infection or tumorigenesis, DCs from young animals are able to induce proliferation of CD 4 + and CD 8 + T cells, respectively. However, the ability to prime CD 4 + and CD 8 + T cells is dampened in aged mice, resulting in decreased proliferation. In the context of autoimmunity, DCs help maintain a balance between immunosuppressive Tregs and inflammatory Th 17 cells. Disturbance of this equilibrium in aged mice may contribute to increase incidence of autoimmune pathologies with advanced age. null, 2(5), 346 -360. Doi: null