Agerelated CCL 12 Aggravates Intracerebral Hemorrhageinduced Brain Injury
Age-related CCL 12 Aggravates Intracerebral Hemorrhage-induced Brain Injury via Recruitment of Macrophages and T Lymphocytes Huang Jiacheng, Yang Guoqiang, Xiong Xiaoyi, Wang Maolin, Yuan Junjie, Zhang Qin, Gong Changxiong, Qiu Zhongming, Meng Zhaoyou, Xu Rui, Chen Qiong, Chen Ru, Xie Lexing, Xie Qi, Zi Wenjie, Jiang Guohui, Zhou Yu, Yang Qingwu 1 Department of Neurology, Xinqiao Hospital, the Army Medical University (Third Military Medical University), Chongqing 400037, China. 1 Central Laboratory, Xinqiao Hospital, the Army Medical University (Third Military Medical University), Chongqing 400037, China. Figure 5. CCL 12 treatment decreases the number of surviving neurons. (A) H&#x 00026; E staining of perihematomal brain tissues from old WT, vehicle-treated and CCL 12 -treated mice after ICH surgery. Scale bars, 200 &#x 003 BC; m top images and 100 &#x 003 BC; m bottom images. (B) TUNEL assay results and quantification of apoptotic cells in perihematomal brain tissues derived from old WT, vehicle-treated and CCL 12 -treated mice after Aging and Disease, 2020, 11(5), 1103 -1115. DOI: 10. 14336/AD. 2019. 1229 ICH surgery. Scale bars, 100 &#x 003 BC; m. (C) FJB staining and quantification of degenerative cells in perihematomal brain tissues derived from old WT, vehicle-treated and CCL 12 -treated mice after ICH surgery. (D) Nissl staining and quantification of Nissl bodies in perihematomal brain tissues derived from old WT, vehicletreated and CCL 12 -treated mice after ICH surgery. Scale bars, 200 &#x 003 BC; m top images and 100 &#x 003 BC; m bottom images. The bar graphs show the means &#x 000 B 1; SDs. n = 5. P -values were determined by ANOVA. &#x 0002 A; P &#x 0003 C; 0. 05; &#x 0002 A; P &#x 0003 C; 0. 01; ns, not significant.
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