Adult Bcell acute lymphoblastic leukemia cells display decreased
Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI 3 K/Akt pathway despite high PTEN protein levels by A. Margarida Gomes, Maria V. D. Soares, Patrícia Ribeiro, Joana Caldas, Vanda Póvoa, Leila R. Martins, Alice Melão, Ana Serra-Caetano, Aida B. de Sousa, João F. Lacerda, and João T. Barata haematol Volume 99(6): 1062 -1068 May 31, 2014 © 2014 by Ferrata Storti Foundation
Immunophenotype and cytogenetics features of B-ALL patient samples. A. Margarida Gomes et al. Haematologica 2014; 99: 10621068 © 2014 by Ferrata Storti Foundation
PI 3 K/Akt and JAK/STAT pathways are constitutively hyper activated in primary B-ALL cells. A. Margarida Gomes et al. Haematologica 2014; 99: 10621068 © 2014 by Ferrata Storti Foundation
PTEN lipid phosphatase activity is down-regulated in adult B-ALL cases despite increased protein expression. A. Margarida Gomes et al. Haematologica 2014; 99: 10621068 © 2014 by Ferrata Storti Foundation
CK 2 regulates PTEN expression and activity in B-ALL cells. A. Margarida Gomes et al. Haematologica 2014; 99: 10621068 © 2014 by Ferrata Storti Foundation
CK 2 and PI 3 K inhibition induce apoptosis of B-ALL cells. A. Margarida Gomes et al. Haematologica 2014; 99: 10621068 © 2014 by Ferrata Storti Foundation
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