ADHESION MOLECULES BIO 480 Regulation of adhesion molecule

ADHESION MOLECULES BIO 480

Regulation of adhesion molecule expression

The in transcription factors of NF-k. B family is an important protein group that regulates the expression of many genes, including adhesion molecules for immune and inflammatory responses.

Regulation • Cytokines such as TNF-α, IL-1β, IL-2, IL-6, GM-CSF, G-CSF, chemokines • Inflammatory enzymes such as NOS, cyclooxygenase, lipoxygenase, phospholipase A 2 • Adhesion molecules such as ICAM-1, VCAM-1, Eselectin • Receptors such as IL-2α chain, TCRβ chain • 1κBα genes

Glucocorticoids, aspirin and IL-10 inhibit the synthesis of some adhesion molecules and reduce transmigration in chronic inflammatory diseases by inhibiting NF-κB activity.

• For normal cellular and organismal homeostasis, proper cell adhesion should be maintained. Some micro. RNAs regulate the basic biological events that drive cell adhesion.

Investigation of micro. RNAs is important both in understanding the cell adhesion biology and in the etiology of a large number of pathological conditions.

• Cell adhesion significantly determines the fate of the cell by modulating intracellular signaling pathways. Therefore, the regulation disorder of various cell adhesion molecules plays a trigger role in the etiology of many human diseases.