Activin A a new leukemiapromoting factor conferring migratory

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Activin. A: a new leukemia-promoting factor conferring migratory advantage to B-cell precursor-acute lymphoblastic leukemic

Activin. A: a new leukemia-promoting factor conferring migratory advantage to B-cell precursor-acute lymphoblastic leukemic cells by Federica Portale, Giulia Cricrì, Silvia Bresolin, Monica Lupi, Stefania Gaspari, Daniela Silvestri, Barbara Russo, Noemi Marino, Paolo Ubezio, Fabio Pagni, Patrizia Vergani, Geertruy Te Kronnie, Maria Grazia Valsecchi, Franco Locatelli, Carmelo Rizzari, Andrea Biondi, Erica Dander, and Giovanna D’Amico haematol Volume 104(3): 533 -545 February 28, 2019 © 2019 by Ferrata Storti Foundation

B-cell precursor-acute lymphoblastic leukemia (BCP-ALL) cells reprogrammed the bone marrow (BM) stroma to produce

B-cell precursor-acute lymphoblastic leukemia (BCP-ALL) cells reprogrammed the bone marrow (BM) stroma to produce high levels of Activin. A. Federica Portale et al. Haematologica 2019; 104: 533 -545 © 2019 by Ferrata Storti Foundation

B-cell precursor-acute lymphoblastic leukemia (BCP-ALL) cells expressed type I and type II Activin. A

B-cell precursor-acute lymphoblastic leukemia (BCP-ALL) cells expressed type I and type II Activin. A receptors. Federica Portale et al. Haematologica 2019; 104: 533 -545 © 2019 by Ferrata Storti Foundation

Activin. A enhanced cell motility, migration and invasion of leukemic cells. Federica Portale et

Activin. A enhanced cell motility, migration and invasion of leukemic cells. Federica Portale et al. Haematologica 2019; 104: 533 -545 © 2019 by Ferrata Storti Foundation

Activin. A enhanced leukemic cell responsiveness to CXCL 12. Federica Portale et al. Haematologica

Activin. A enhanced leukemic cell responsiveness to CXCL 12. Federica Portale et al. Haematologica 2019; 104: 533 -545 © 2019 by Ferrata Storti Foundation

Activin. A increased CXCL 12 -induced calcium mobilization and actin polymerization. Federica Portale et

Activin. A increased CXCL 12 -induced calcium mobilization and actin polymerization. Federica Portale et al. Haematologica 2019; 104: 533 -545 © 2019 by Ferrata Storti Foundation

Activin. A impaired CXCL 12 -driven migration of healthy CD 34+ cells. Federica Portale

Activin. A impaired CXCL 12 -driven migration of healthy CD 34+ cells. Federica Portale et al. Haematologica 2019; 104: 533 -545 © 2019 by Ferrata Storti Foundation

Inflammation contributed to Activin. A production by bone marrow-mesenchymal stem cells (BMMSCs). Federica Portale

Inflammation contributed to Activin. A production by bone marrow-mesenchymal stem cells (BMMSCs). Federica Portale et al. Haematologica 2019; 104: 533 -545 © 2019 by Ferrata Storti Foundation

NALM-6 cells stimulated with Activin. A showed an increased ability to engraft in vivo

NALM-6 cells stimulated with Activin. A showed an increased ability to engraft in vivo in the bone marrow (BM), meninges and brain of NSG mice. Federica Portale et al. Haematologica 2019; 104: 533 -545 © 2019 by Ferrata Storti Foundation

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