ACCURACY OF RENAL FUNCTION ESTIMATING EQUATIONS COMPARED TO

ACCURACY OF RENAL FUNCTION ESTIMATING EQUATIONS COMPARED TO IOHEXOL CLEARANCE IN CRITICALLY ILL CHILDREN Dhont E 1, Windels C 2 , Van Der Heggen T 3, De Jaeger A 1, Willems J 1, Croubels S 4, De Baere S 4, Vande Walle J 5, De Paepe P 6, De Cock P 1, 7 Pediatric Intensive Care Unit, University Hospital, Ghent, Belgium, 2 Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium, 3 Pediatrics Department, University Hospital, Ghent, Belgium, 4 Faculty of Veterinary Medicine, Department of Pharmacology, Toxicology and Biochemistry, Ghent University, Ghent, Belgium, 5 Paediatric Nephrology Department, University Hospital, Ghent, Belgium, 6 Heymans Institute, University Hospital, Ghent, Belgium, 7 Clinical Pharmacy, University Hospital, Ghent, Belgium INTRODUCTION RESULTS • Accurate assessment of renal function is crucial in intensive care • Both acute kidney injury and augmented renal clearance may compromise outcome • Common formulas to estimate glomerular filtration rate (GFR) are proven unreliable in critically ill adults OBJECTIVES Our aim was to evaluate the performance of 26 GFR estimating formulas based on creatinine (Screat), cystatin C (Cys. C) and betatrace protein (BTP) in comparison with measured plasma iohexol clearance (CLiohex) in critically ill children. METHODS • prospective, interventional study • Measurement of 6 -points plasma iohexol clearance over a 6 hours interval • Estimation of GFR by Screat-based formulas (n=10) , serum cys. C-based formulas (n=11), serum BTP -based formulas (n=2) and formulas combining these biomarkers (n=3) • Accuracy of GFR estimating formulas was determined as the percentage of GFR estimates within 10% and 30% of measured GFR by Cliohex (P 10 and P 30) • Performance of e. GFR formulas was also assessed separately in subgroups with Cliohex <100 ml/min/1. 73 m 2 and with Cliohex > 100 ml/min/1. 73 m 2 CONCLUSIONS - Serum creatinine and its derived equations are unreliable to estimate GFR in critically ill children - Individual e. GFR formulas based on serum creatinine, serum cystatin C or serum betatrace protein all show moderate to low accuracy compared with measured plasma iohexol clearance in critically ill children - Combining e. GFR formulas yields a significantly higher accuracy to estimate GFR - Plasma iohexol clearance could offer a safe alternative to determine renal function in pediatric intensive care patients Contact: evelyn. dhont@uzgent. be RESEARCH POSTER PRESENTATION TEMPLATE © 2019 www. Poster. Presentations. com

RESEARCH POSTER PRESENTATION TEMPLATE © 2019 www. Poster. Presentations. com