Abstract Genetics Comprehensive Review Worm Book Worm Base

Abstract Genetics Comprehensive Review: Worm. Book Worm. Base: An Information Resource for Research of Caenorhabditis elegans and related nematodes. Raymond Lee and Worm. Base Consortium. Division of Biology, California Institute of Technology, Pasadena, CA 91125 and www. wormbase. org. The goal of Worm. Base is to provide a knowledge environment to facilitate further research with C. elegans and related nematodes. We maintain a database, extract information from the literature, and disseminate integrated knowledge via the WWW. Information includes complete genome sequences, developmental cell lineages, neural circuit maps, and extensive genetic analyses that make functional connections between the genome, development, anatomy, and physiology. To allow rapid and easy access of available content, Worm. Base provides Web pages that focus on special topics, e. g. Gene page, which contains summaries of everything that is known about a gene. Also, users can synthesize complex queries using tools such as Worm. Mart, an interface based on Bio. Mart. For power users, we offer FTP downloads of all of our data and software, and we provide directions for building local mirrors. To keep up with the rapid growth of research literature, we update our database every three weeks. But to ensure comparability between large-scale analyses, we maintain a stable version every ten releases. Sequence Homology Literature Query Tool: Textpresso Completing its functionality as a knowledge portal, Worm. Base integrates with related services: Textpresso, a primary literature search engine, and Worm. Book, a collection of expert-written chapters about C. elegans biology. Since its inception in 2000, Worm. Base has become an indispensable resource for C. elegans researchers. Going forward, a new focus will be on comparative genomics as several other nematode genomes are being sequenced. Gene Page: Summary of a Gene Database Query Tool - Worm. Mart Comparative Genomics (Future) (Being) Sequenced Genome Documentation & User Feedback www. wormbase. org/wiki People and Funding California Institute of Technology Igor Antoshechkin Carol Bastiani Juancarlos Chan Wen Chen Ranjana Kishore Raymond Lee Hans-Michael Mueller Cecilia Nakamura Andrei Petcherski Gary Schindelman Erich Schwarz Paul Sternberg Kimberly Van Auken Daniel Wang Washington University at St. Louis Tamberlyn Bieri Darin Blasiar Phil Ozersky John Spieth Wellcome Trust Sanger Institute Paul Davis Richard Durbin Michael Han Anthony Rogers Mary Ann Tuli Gary Williams Cold Spring Harbor Laboratory Payan Canaran Jack Chen Tristan Fiedler Todd Harris Sheldon Mc. Kay Will Spooner Lincoln Stein Support by National Human Genome Research Institute at the US National Institutes of Health and the British Medical Research Council