A students work without solutions manual 10 problemsnight

  • Slides: 67
Download presentation
“A” students work (without solutions manual) ~ 10 problems/night. Dr. Alanah Fitch Flanner Hall

“A” students work (without solutions manual) ~ 10 problems/night. Dr. Alanah Fitch Flanner Hall 402 508 -3119 [email protected] edu Office Hours Th&F 2 -3: 30 pm Module #17 B: Acid Base Ionization Computations

To determine if our protein unfolds or not is it sufficient to know the

To determine if our protein unfolds or not is it sufficient to know the Ka and Kb Values of the functional groups?

2 1 3 D structure of ALAD directs Reactants into proper orientation 3 D

2 1 3 D structure of ALAD directs Reactants into proper orientation 3 D structure controlled by proper hydrogen and ionic bonds, p. H dependent!!!!!!!

http: //www. jenner. ac. uk/PPD/ http: //www. biology. arizona. edu/biochemistry/problem_sets/aa/aa. htm Ionization constants for

http: //www. jenner. ac. uk/PPD/ http: //www. biology. arizona. edu/biochemistry/problem_sets/aa/aa. htm Ionization constants for proteins - Zn 2+ - - cysteine R refers to rest of protein Phosphoenolate carboxylase, human, cys Control of protein shape is due to fraction of sites charged

Protein folding due to FRACTION of sites charged Hemeglobin

Protein folding due to FRACTION of sites charged Hemeglobin

% Ionized (dissociated) This seems pretty straight forward

% Ionized (dissociated) This seems pretty straight forward

Calculating [A-] This will require knowing [H 3 Oaq+] AND a new vocabulary for

Calculating [A-] This will require knowing [H 3 Oaq+] AND a new vocabulary for comparing the solution acidity from experiment to experiment Ka and Kb tell us about the possibility Of donating protons, not what the solution Acidity is Define another comparison number: p. H

“A” students work (without solutions manual) ~ 10 problems/night. Dr. Alanah Fitch Flanner Hall

“A” students work (without solutions manual) ~ 10 problems/night. Dr. Alanah Fitch Flanner Hall 402 508 -3119 [email protected] edu Office Hours Th&F 2 -3: 30 pm Module #17 B: Acid Base Ionization Computations p. H, p. OH, p. Ka

LAZY Chemists are _____ To shorten calculations use log

LAZY Chemists are _____ To shorten calculations use log

Assumption that 55. 5 molar is relative unchanged

Assumption that 55. 5 molar is relative unchanged

p. H scale runs from 0 to 14 Which is more Acidic?

p. H scale runs from 0 to 14 Which is more Acidic?

acid/base ave [H+] base blood 5. 01 x 10 -8 saliva 1 x 10

acid/base ave [H+] base blood 5. 01 x 10 -8 saliva 1 x 10 -7 acid urine 2. 51 x 10 -7 cow’s milk 3. 54 x 10 -7 cheese 7. 94 x 10 -6 p. H p. OH ave [OH-] 7. 3 6. 7 7 You do the rest # is slightly larger than 10 -8, so I know it is 7…. . something 14 -7. 3=6. 7 1. 99 x 10 -7

What are the two p. Kas? - What is the Ka of a compound

What are the two p. Kas? - What is the Ka of a compound Whose p. Ka is 3. 7? cysteine

“A” students work (without solutions manual) ~ 10 problems/night. Dr. Alanah Fitch Flanner Hall

“A” students work (without solutions manual) ~ 10 problems/night. Dr. Alanah Fitch Flanner Hall 402 508 -3119 [email protected] edu Office Hours Th&F 2 -3: 30 pm Module #17 B: Acid Base Ionization Computations

Calculating [A-] This will require an equilibrium calculation

Calculating [A-] This will require an equilibrium calculation

Generalized Strategy involves comparing Kas 1. Write down ALL possible reactions involving a proton

Generalized Strategy involves comparing Kas 1. Write down ALL possible reactions involving a proton 2. Excluding water, identify all the proton donors as 1. Strong acid a. Strong electrolyte: HNO 3, HCl, H 2 SO 4 (No Clean Socks) b. Give all strong acid protons to water or alpha dog c. Calculate hydronium conc. d. Calculate p. H 2. Weak Acid a. Identify strongest acid (omega dog, can not hold protons) b. Has largest Ka; smallest charge density anion c. Calculate how many protons omega gives up (equil) d. Calculate p. H e. Use to determine what alpha gets

Example Calculations 1. HCl 2. Acetic acid (vinegar) 2. HF 3. B(OH)3 (Boric acid

Example Calculations 1. HCl 2. Acetic acid (vinegar) 2. HF 3. B(OH)3 (Boric acid (eye wash)) 4. Mixture (HF and phenol) 5. Mixture (H 2 SO 4, HSO 4 -) 6. Triethylamine 7. Na. Acetate 8. Our heme example Calculate the p. H of 0. 004 M HCl

Generalized Strategy involves comparing Kas 1. Write down ALL possible reactions involving a proton

Generalized Strategy involves comparing Kas 1. Write down ALL possible reactions involving a proton 2. Excluding water, identify all the proton donors as 1. Strong acid a. Strong electrolyte: HNO 3, HCl, H 2 SO 4 (No Clean Socks) Omega dog b. Give all strong acid protons to water or alpha present c. Calculate hydronium conc. d. Calculate p. H

Scientific notation allows you to quickly check if Your answer is in the right

Scientific notation allows you to quickly check if Your answer is in the right “ballpark” p. H has to be slightly less Than 3

Example Calculations 1. HCl 2. Acetic acid (vinegar) 2. HF 3. B(OH)3 (Boric acid

Example Calculations 1. HCl 2. Acetic acid (vinegar) 2. HF 3. B(OH)3 (Boric acid (eye wash)) 4. Mixture (HF and phenol) 5. Mixture (H 2 SO 4, HSO 4 -) 6. Triethylamine 7. Na. Acetate 8. Our heme example

Example: What is the % ionization of commercial vinegar? The label reads 5% acidity

Example: What is the % ionization of commercial vinegar? The label reads 5% acidity (by weight). Vinegar is acetic acid which has the formula HC 2 H 3 O 2. (CH 3 COOH) Ka = 1. 8 x 10 -5 Density of 5% acetic acid 1. 0023 g/m. L 1. Write down ALL possible reactions involving a proton 2. Excluding water, identify all the proton donors as 1. Strong acid a. Strong electrolyte: HNO 3, HCl, H 2 SO 4 (None) 2. Weak Acid: a. Calculate how many protons omega gives up (equil)

Example: What is the % ionization of commercial vinegar? The label reads 5% acidity

Example: What is the % ionization of commercial vinegar? The label reads 5% acidity (by weight). Vinegar is acetic acid which has the formula HC 2 H 3 O 2. (CH 3 COOH) Ka = 1. 8 x 10 -5 Density of 5% acetic acid 1. 0023 g/m. L Know % by wt. Ka = 1. 8 x 10 -5 Don’t Know Need the initial molarity need the final dissociation

Why complicate this situation by adding in 10 -7 When we get rid off

Why complicate this situation by adding in 10 -7 When we get rid off it with an assumption? Because it creates a habit necessary of multiple rx H 2 O OH 55. 5 10 -7 HC 2 H 3 O 2 stoic 1 1 conc. init 5% 0 [Init] 0. 8355 0 Change -x +x Assume 0. 8355>>x +x [Equil] 0. 8355 +x What is the % ionization of commercial vinegar? The label reads 5% acidity (by weight). Density of 5% acetic acid is 1. 0023 g/m. L. Vinegar is acetic acid which has the formula HC 2 H 3 O 2. (CH 3 COOH) Ka = 1. 8 x 10 -5 H+ 10 -7 H+ 1 10 -7 +x 10 -7 << x +x

HA 0. 8355>>x Assume A +x H+ 10 -7 << x Original sig figs

HA 0. 8355>>x Assume A +x H+ 10 -7 << x Original sig figs were = 0. 83 So if we round to 2 sig fig, have Same answer Check: + p. H =-log(0. 003878)= 2. 41 Sig figs

What is the % ionization of commercial vinegar? The label reads 5% acidity (by

What is the % ionization of commercial vinegar? The label reads 5% acidity (by weight). Density of 5% acetic acid is 1. 0023 g/m. L. Vinegar is acetic acid which has the formula HC 2 H 3 O 2. (CH 3 COOH) Ka = 1. 8 x 10 -5

How does % dissociation or ionization vary with concentration? [Acetic Acid] 1. 00 M

How does % dissociation or ionization vary with concentration? [Acetic Acid] 1. 00 M 0. 835 M 0. 1 M % ionization 0. 42% 0. 46% 1. 3% Observations? % ionization increases with the lower molarity. Why should this be so? What is the % ionization of commercial vinegar? The label reads 5% acidity (by weight). Density of 5% acetic acid is 1. 0023 g/m. L. Vinegar is acetic acid which has the formula HC 2 H 3 O 2. (CH 3 COOH) Ka = 1. 8 x 10 -5

Dilute by 10 (make less concentrated): What does this tell us, if anything? We

Dilute by 10 (make less concentrated): What does this tell us, if anything? We have too many reactants, need to shift to the right, or dissociate some more. general rule of thumb: dilution gives more dissociation.

Example Calculations 1. HCl 2. Acetic acid (vinegar) 3. HF 4. B(OH)3 (Boric acid

Example Calculations 1. HCl 2. Acetic acid (vinegar) 3. HF 4. B(OH)3 (Boric acid (eye wash)) (students Do this one yourself) 5. Mixture (HF and phenol) 6. Mixture (H 2 SO 4, HSO 4 -) 7. Triethylamine 8. Na. Acetate 9. Our heme example

Calculate the F- of a solution of 1. 00 M HF. Ka= 7. 2

Calculate the F- of a solution of 1. 00 M HF. Ka= 7. 2 x 10 -4 1. Write down ALL possible reactions involving a proton 2. Excluding water, identify all the proton donors as 1. Strong acid a. Strong electrolyte: HNO 3, HCl, H 2 SO 4 (No Clean Socks) No Strong Acids (SA) 2. Weak Acid a. Identify strongest acid (omega dog, can not hold protons) b. Has largest Ka; smallest charge density anion c. Calculate how many protons omega gives up (equil)

stoic. Init Change Assum Equil H 2 O 55. 5 HF(aq) 1 1. 0

stoic. Init Change Assum Equil H 2 O 55. 5 HF(aq) 1 1. 0 -x 1>>x 1 H+ 10 -7 H+from HF 1 10 -7 +x 10 -7 <<x x OH 10 -7 F 1 0 +x x

Init Change Assum Equil HF(aq) 1. 0 -x 1>>x 1 H+from HF F 10

Init Change Assum Equil HF(aq) 1. 0 -x 1>>x 1 H+from HF F 10 -7 0 +x +x 10 -7 <<x x x Check assumptions Calculate the p. H of a solution of 1. 00 M HF. K 1 = 7. 2 x 10 -4 Sig fig is here

Init Change Assum Equil HF(aq) 1. 0 -x 1>>x 1 Calculate the F- of

Init Change Assum Equil HF(aq) 1. 0 -x 1>>x 1 Calculate the F- of a solution of 1. 00 M HF. K 1 = 7. 2 x 10 -4 H+from HF F 10 -7 0 +x +x 10 -7 <<x x x

Example: Boric acid is commonly used in eyewash solutions to neutralize bases splashed in

Example: Boric acid is commonly used in eyewash solutions to neutralize bases splashed in the eye. It acts as a monoprotic acid, but the dissociation reaction looks different. Calculate the p. H of a 0. 75 M solution of boric acid, and the concentration of B(OH)4 -. 1. Write down ALL possible reactions involving a proton 2. Identify proton donors 1. strong acids: No Clean Socks? 2. Weak acids: No SA Students do B(OH)3 This on your own

Set up ICAE chart stoic [Init] Change Assume Equil Students do This on your

Set up ICAE chart stoic [Init] Change Assume Equil Students do This on your own H 2 O 55. 5 B(OH)3 + H 2 O 1 n. a. 0. 75 -x 0. 75>>x 0. 75 check? ? two assumptions. B(OH) OHH+ 10 -7 B(OH)4 - + H+ 1 1 0 10 -7 +x +x x 10 -7<<x x x + H 2 O B(OH)4 - + H+ Ka = 5. 8 x 10 -10 Calculate the p. H of a 0. 75 M solution of boric acid. 3

[Init] Change Assume Equil B(OH)3 + H 2 O 0. 75 -x 0. 75>>x

[Init] Change Assume Equil B(OH)3 + H 2 O 0. 75 -x 0. 75>>x 0. 75 B(OH)4 - + H+ 0 10 -7 +x +x x 10 -7<<x x x yes check? ? two assumptions. B(OH) Sig fig Students do This on your own + H 2 O B(OH)4 - + H+ Ka = 5. 8 x 10 -10 Calculate the p. H of a 0. 75 M solution of boric acid. 3

Example Calculations 1. HCl 2. Acetic acid (vinegar) 3. HF 4. B(OH)3 (Boric acid

Example Calculations 1. HCl 2. Acetic acid (vinegar) 3. HF 4. B(OH)3 (Boric acid (eye wash)) (students Do this one yourself) 5. Mixture (HF and phenol) 6. Mixture (H 2 SO 4, HSO 4 -) 7. Triethylamine 8. Na. Acetate 9. Our heme example

Mixtures of Acids Calculate the p. H of a solution that contains 1. 0

Mixtures of Acids Calculate the p. H of a solution that contains 1. 0 M HF and 1. 0 M HOC 6 H 5. Calculate the conc. of -OC 6 H 5 at this concentration. 1. Write down ALL possible reactions involving a proton 2. Excluding water, identify all the proton donors as 1. Strong acid NONE 2. Weak Acid Identify strongest acid (omega dog, can not hold protons) Has largest Ka; smallest charge density anion Calculate how many protons omega gives up (equil) Calculate p. H (Use to determine what alpha gets)

HF will control the proton concentration, but Should include all possible sources to remind

HF will control the proton concentration, but Should include all possible sources to remind ourselves. H 2 O 55. 5 HF + H 2 O 1 n. a. 1. 0 -x 1. 0>>x 1. 0 stoic [Init] Change Assume Equil OH 10 -7 F- + 1 0 +x x x check? ? H two assumptions. +F K = 7. 2 x 10 HF HOC 6 H 5 + - H+ + -OC 6 H 5 a -4 Ka = 1. 8 x 10 -5 H+ 10 -7 H+ 1 10 -7 +x 10 -7<<x x Calculate the p. H of a solution that contains 1. 0 M HF and 1. 0 M HOC 6 H 5. Calculate the conc. of -OC 6 H 5 at this concentration.

stoic [Init] Change Assume Equil HF + H 2 O 1 n. a. 1.

stoic [Init] Change Assume Equil HF + H 2 O 1 n. a. 1. 0 -x 1. 0>>x 1. 0 F- + 1 0 +x x x H+ 1 10 -7 +x 10 -7<<x x Check assumptions: Sig fig = 1. 0 Sig fig = 0. 027

stoic [Init] Change Assume Equil HF + H 2 O 1 n. a. 1.

stoic [Init] Change Assume Equil HF + H 2 O 1 n. a. 1. 0 -x 1. 0>>x 1. 0 F- + 1 0 +x x x H+ 1 10 -7 +x 10 -7<<x x Calculate the p. H of a solution that contains 1. 0 M HF and 1. 0 M HOC 6 H 5. Calculate the conc. of -OC 6 H 5 at this concentration.

Example Calculations 1. HCl 2. Acetic acid (vinegar) 3. HF 4. B(OH)3 (Boric acid

Example Calculations 1. HCl 2. Acetic acid (vinegar) 3. HF 4. B(OH)3 (Boric acid (eye wash)) (students Do this one yourself) 5. Mixture (HF and phenol) 6. Mixture (H 2 SO 4, HSO 4 -) 7. Triethylamine 8. Na. Acetate 9. Our heme example

Example: calculate the p. H of 0. 0010 M sulfuric acid 1. Write down

Example: calculate the p. H of 0. 0010 M sulfuric acid 1. Write down ALL possible reactions involving a proton 2. Excluding water, identify all the proton donors as 1. Strong acid a. Strong electrolyte: HNO 3, HCl, H 2 SO 4 (No Clean Socks) b. Give all strong acid protons to water or alpha dog

1 2 3 Pure Water Control/complete stoic. [init] complete stoic. H 2 O 55.

1 2 3 Pure Water Control/complete stoic. [init] complete stoic. H 2 O 55. 5 H 2 SO 4 1. 001 0 [Init] Change Assume? [Equil] Example: calculate the p. H of 0. 0010 M sulfuric acid; Ka 2 = 1. 2 x 10 -2 OH 10 -7 HSO 41 0 0. 001 HSO 41 0. 0010 -x 0. 001>x 0. 001 H+ 10 -7 H+ 1 10 -7 0. 001+10 -7 H+ SO 421 1 0. 0010 0 +x +x 0. 001>x +x 0. 001 x NO!

stoic. [Init] Change Assume? [Equil] HSO 41 0. 0010 -x 0. 001>x 0. 001

stoic. [Init] Change Assume? [Equil] HSO 41 0. 0010 -x 0. 001>x 0. 001 -x H+ 1 0. 0010 +x 0. 001>x 0. 001+x SO 421 0 +x +x x Here is our first example in which we can not Make assumptions Example: calculate the p. H of 0. 0010 M sulfuric acid; Ka 2 = 1. 2 x 10 -2

-Solution gives a neg Number which is not allowed [SO 42 -]=x [H+]=0. 001

-Solution gives a neg Number which is not allowed [SO 42 -]=x [H+]=0. 001 +0. 000865 0. 001865 p. H=-log(0. 001865)=2. 73

Successive Approximations (iterations) Alternative Strategy to going to “exact equil. Expression” ITERATIVE SOLUTIONS Why?

Successive Approximations (iterations) Alternative Strategy to going to “exact equil. Expression” ITERATIVE SOLUTIONS Why? – because the real body or real world Is much too complex to always be able to Find an exact equilibrium expression

Calculate proton concentration of 0. 100 M HNO 2 using the iterative method (Ka=6.

Calculate proton concentration of 0. 100 M HNO 2 using the iterative method (Ka=6. 0 x 10 -4) Pure Water H 2 O OHH+ 1 55. 5 10 -7 HNO 2 H+ stoic. 1 1 1 0 10 -7 2 [Init] Change -x +x +x Assum 0. 1>>x x x>>10 -7 [Equil] 0. 1 x x Calc 7. 7 x 10 -3 New Equil 0. 1 -7. 7 x 10 -3 x’’ 3 New calc 7. 44 x 10 -3 -3 x’’’ New Equil 0. 1 -7. 44 x 10 x’’’ 4 New new Calc 7. 45 x 10 -3

Converging, plausible answer for iterative method: 0. 100 M HNO 2, Ka=6. 0 x

Converging, plausible answer for iterative method: 0. 100 M HNO 2, Ka=6. 0 x 10 -4 Can Skip This for BLB

“A” students work (without solutions manual) ~ 10 problems/night. Dr. Alanah Fitch Flanner Hall

“A” students work (without solutions manual) ~ 10 problems/night. Dr. Alanah Fitch Flanner Hall 402 508 -3119 [email protected] edu Office Hours Th&F 2 -3: 30 pm Module #17 B: Acid Base Ionization Computations Weak Bases

Example Calculations 1. HCl 2. Acetic acid (vinegar) 3. HF 4. B(OH)3 (Boric acid

Example Calculations 1. HCl 2. Acetic acid (vinegar) 3. HF 4. B(OH)3 (Boric acid (eye wash)) (students Do this one yourself) 5. Mixture (HF and phenol) 6. Mixture (H 2 SO 4, HSO 4 -) 7. Triethylamine 8. Na. Acetate 9. Our heme example

Calculation with Weak Base Calc. the [OH], [H], and p. H of 0. 20

Calculation with Weak Base Calc. the [OH], [H], and p. H of 0. 20 M solns of triethylamine, Kb = 4. 0 x 10 -4 1 stoic 2 [Init] Change Assum Equil B 1 0. 20 -x 0. 20>>x 0. 20 H 2 O 55. 5 H 2 O 1 Calc. the [OH], [H], and p. H of 0. 20 M solns of triethylamine, Kb = 4. 0 x 10 -4 H+ 10 -7 BH+ 1 0 +x x x OH 10 -7 OH 1 10 -7 +x 10 -7 < x x

1 stoic 2 [Init] Change Assum Equil B 1 0. 20 -x 0. 20>>x

1 stoic 2 [Init] Change Assum Equil B 1 0. 20 -x 0. 20>>x 0. 20 H 2 O 55. 5 H 2 O 1 H+ 10 -7 BH+ 1 0 +x x x OH 10 -7 OH 1 10 -7 +x 10 -7 < x x Rounds to 0. 2 Rounds to 0. 0089 Calc. the [OH], [H], and p. H of 0. 20 M solns of triethylamine, Kb = 4. 0 x 10 -4

“A” students work (without solutions manual) ~ 10 problems/night. Dr. Alanah Fitch Flanner Hall

“A” students work (without solutions manual) ~ 10 problems/night. Dr. Alanah Fitch Flanner Hall 402 508 -3119 [email protected] edu Office Hours Th&F 2 -3: 30 pm Module #17 B: Acid Base Ionization Computations Salts

Example Calculations 1. HCl 2. Acetic acid (vinegar) 3. HF 4. B(OH)3 (Boric acid

Example Calculations 1. HCl 2. Acetic acid (vinegar) 3. HF 4. B(OH)3 (Boric acid (eye wash)) (students Do this one yourself) 5. Mixture (HF and phenol) 6. Mixture (H 2 SO 4, HSO 4 -) 7. Triethylamine 8. Na. Acetate 9. Our heme example

Write all reactions involving protons, hydroxides Determine who is omega and will donate Hmm,

Write all reactions involving protons, hydroxides Determine who is omega and will donate Hmm, a slight problem – we don’t know Kb If we place Na acetate in solution (to make a 0. 1 M solution) what are the main species present? What will be the p. H of the solution? Ka = 1. 8 x 10 -5

+ If we place Na acetate in solution (to make a 0. 1 M

+ If we place Na acetate in solution (to make a 0. 1 M solution) what are the main species present? What will be the p. H of the solution? Ka = 1. 8 x 10 -5

1 2 stoich [Init] Change Sum Assume [Equil] H 2 O H+ OH 55.

1 2 stoich [Init] Change Sum Assume [Equil] H 2 O H+ OH 55. 5 10 -7 CH 3 COO- + H 2 O = CH 3 COOH + OH 1 1 1 0 10 -7 -x +x 10 -7 +x 0. 1 -x 0+x 10 -7 +x x<<<0. 1 x>>>10 -7 0. 1 x x If we place Na acetate in solution (to make a 0. 1 M solution) what are the main species present? What will be the p. H of the solution? Ka = 1. 8 x 10 -5

stoich [Init] Change Sum Assume [Equil] CH 3 COO- + H 2 O =

stoich [Init] Change Sum Assume [Equil] CH 3 COO- + H 2 O = CH 3 COOH + OH 1 1 1 0 10 -7 -x +x 10 -7 +x 0. 1 -x 0+x 10 -7 +x x<<<0. 1 x>>>10 -7 0. 1 x x yes X 100 rule No If we place Na acetate in solution (to make a 0. 1 M solution) what are the main species present? What will be the p. H of the solution? Ka = 1. 8 x 10 -5

CH 3 COO- + H 2 O = CH 3 COOH + OHstoich 1

CH 3 COO- + H 2 O = CH 3 COOH + OHstoich 1 1 1 [Init] 0. 1 0 10 -7 Change -x +x 10 -7 +x Sum 0. 1 -x 0+x 10 -7 +x Assume x<<<0. 1 x>>>10 -7 [Equil] 0. 1 x x Equil new 0. 1 -x x x+10 -7 If we place Na acetate in solution (to make a 0. 1 M solution) what are the main species present? What will be the p. H of the solution? Ka = 1. 8 x 10 -5

Before we got 7. 45 x 10 -6

Before we got 7. 45 x 10 -6

“A” students work (without solutions manual) ~ 10 problems/night. Dr. Alanah Fitch Flanner Hall

“A” students work (without solutions manual) ~ 10 problems/night. Dr. Alanah Fitch Flanner Hall 402 508 -3119 [email protected] edu Office Hours Th&F 2 -3: 30 pm Module #17 B: Acid Base Ionization Computations Biological Chemistry

Example Calculations 1. HCl 2. Acetic acid (vinegar) 3. HF 4. B(OH)3 (Boric acid

Example Calculations 1. HCl 2. Acetic acid (vinegar) 3. HF 4. B(OH)3 (Boric acid (eye wash)) (students Do this one yourself) 5. Mixture (HF and phenol) 6. Mixture (H 2 SO 4, HSO 4 -) 7. Triethylamine 8. Na. Acetate 9. Our heme example

Protein folding due to FRACTION of sites charged Hemeglobin

Protein folding due to FRACTION of sites charged Hemeglobin

Which p. H (2, 7, 11) is most favorable for the formation of a

Which p. H (2, 7, 11) is most favorable for the formation of a hydrogen bond between Val and tyr in hemoglobin Let’s start by calculating % ionized at each p. H Mass balance

Which p. H (2, 7, 11) is most favorable for the formation of a

Which p. H (2, 7, 11) is most favorable for the formation of a hydrogen bond between Val and tyr in hemoglobin Repeat procedure With tyrosine

Which p. H is best?

Which p. H is best?

“A” students work (without solutions manual) ~ 10 problems/night. Dr. Alanah Fitch Flanner Hall

“A” students work (without solutions manual) ~ 10 problems/night. Dr. Alanah Fitch Flanner Hall 402 508 -3119 [email protected] edu Office Hours Th&F 2 -3: 30 pm Module #17 B: Acid Base Ionization Computations