6 5 NEURONS AND SYNAPSES The image shows

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6. 5 NEURONS AND SYNAPSES The image shows a tiny segment of a human

6. 5 NEURONS AND SYNAPSES The image shows a tiny segment of a human brain the lines show neurons and the dots show synapses. The image is intended to illustrate both how complex even a small mammal's brain is and additionally how important the synapses between neurons are; it is the synapses that drive communication and conscious thought. With the exception of the memory center the number of cells in the human brain does not increase after birth, what increase is the number of connections and hence synapses between neurons.

6. 5 • Essential idea: Neurons transmit the message, synapses modulate the message.

6. 5 • Essential idea: Neurons transmit the message, synapses modulate the message.

What would it be like to feel no pain? • https: //youtu. be/m 5

What would it be like to feel no pain? • https: //youtu. be/m 5 B 20 Vvz. Wq. A

6. 5. U 1 Neurons transmit electrical impulses. • The Nervous System allows organisms

6. 5. U 1 Neurons transmit electrical impulses. • The Nervous System allows organisms to respond to external and internal stimuli • It consists of: • Brain and spinal cord – Central Nervous System (CNS) • Sensory Receptors & Peripheral Nerves – Peripheral Nervous System (PNS) • Neurons – functional unit of the nervous system; specialized cells for transmitting electrical and chemical signals

 • Anatomy of a Nerve Cell: 1. Cell body – contains nucleus, most

• Anatomy of a Nerve Cell: 1. Cell body – contains nucleus, most of the cytoplasm and most of the organelles • Dendrites and axon extend from the cell body 2. Dendrites – short and highly branched • Receive stimulus and send to cell body Cell body Dendrites

3. Axon – conducts impulses away from the cell body to another neuron or

3. Axon – conducts impulses away from the cell body to another neuron or to a muscle or gland • Microscopic in diameter but may extend a meter or more in length • Divides at the end to form terminal branches that end in synaptic terminals – in motor neurons these are called motor end plates and send messages to muscles • Synaptic terminals release neurotransmitters (chemicals) that transmit impulse across the synapse (gap between neurons)

4. Myelin Sheath – fatty material surrounding the axons of neurons of the PNS;

4. Myelin Sheath – fatty material surrounding the axons of neurons of the PNS; speeds up transmission of impulse • Composed of Schwann cells that form insulation • Nodes of Ranvier – gaps between Schwann cells

In Motor neurons these are called motor end plates

In Motor neurons these are called motor end plates

 • In the PNS: • Nerves consist of hundreds or thousands of axons

• In the PNS: • Nerves consist of hundreds or thousands of axons wrapped together in connective tissue • Cell bodies are usually grouped together in masses called ganglia • In the CNS: • Bundles of axons are called tracts or pathways instead of nerves • Collection of cell bodies are called nuclei

 • Types of Neurons: 1. Sensory (afferent) neurons – conduct impulses into CNS

• Types of Neurons: 1. Sensory (afferent) neurons – conduct impulses into CNS from the periphery (sensory impulses) • Pick up stimulus from sensory receptors – mechanoreceptors, chemoreceptors, thermoreceptors, photoreceptors

2. Interneurons (associated neurons/relay neurons) – afferent neurons usually transmit impulses to interneurons •

2. Interneurons (associated neurons/relay neurons) – afferent neurons usually transmit impulses to interneurons • Located within CNS • Neurons that integrate input and output • Integration involves sorting and interpreting incoming sensory information and determining the appropriate response • Forms connecting lines between sensory and motor neurons Brain & Spinal cord

3. Motor (efferent) neurons – transmit messages from CNS to effectors (muscle or gland)

3. Motor (efferent) neurons – transmit messages from CNS to effectors (muscle or gland) Sensory receptors, afferent and efferent neurons are part of the Peripheral Nervous System Afferent (input – “inform” CNS of changing conditions) Efferent (output – transmit the “decisions” of the CNS) http: //www. siumed. edu/~dking 2/ssb/neuron. htm#4 b

ion of the Nervous System

ion of the Nervous System

PNS Motor Division Autonomic NS :

PNS Motor Division Autonomic NS :

6. 5. U 3 Neurons pump sodium and potassium ions across their membranes to

6. 5. U 3 Neurons pump sodium and potassium ions across their membranes to generate a resting potential. Membrane potential is the difference in electrical charge across the plasma membrane Resting Potential • Resting potential is the potential difference across a nerve cell membrane when it is not being stimulated. • Slight excess of positive ions outside the membrane and slight excess of negative ions inside the membrane ØMore negatively charged inside the cell compared to the interstitial fluid outside • Resting potential is normally about -70 millivolts (m. V) • Membrane of neuron is polarized due to unequal distribution of ions – as a result, the cell can produce an action potential (nerve impulse)

6. 5. U 3 Neurons pump sodium and potassium ions across their membranes to

6. 5. U 3 Neurons pump sodium and potassium ions across their membranes to generate a resting potential. • Na+ concentration is 10 x greater outside the cell and K+ concentration is 10 x greater inside the cell • Sodium-potassium pumps in the membrane pump Na+ out and K+ in • K+ tends to leak out by diffusion through ion channels causing further negative charge inside as compared to outside of cell • Ion channels that allow the passage of Na+ are closed at resting potential

6. 5. U 4 An action potential consists of depolarization and repolarization of the

6. 5. U 4 An action potential consists of depolarization and repolarization of the neuron. Action Potential • Depolarization is a change from the negative resting potential to the positive action potential • Action potential (nerve impulse) is the potential difference produced across the plasma membrane of the nerve cell when stimulated, reversing the resting potential from about -70 m. V to +40 m. V. • Repolarization is when the resting potential is re-established after a nerve impulse has been transmitted.

6. 5. U 5 Nerve impulses are action potentials propagated along the axons of

6. 5. U 5 Nerve impulses are action potentials propagated along the axons of neurons. AND 6. 5. U 9 A nerve impulse is only initiated if the threshold potential is reached. Action Potential • Stimulation – all or none response • Threshold stimulation – minimum amount needed for depolarization to occur • Causes Na+ ion channels to open allowing Na+ to rush into interior of cell (depolarization) • Disturbs adjacent areas – Na+ channels open causing a depolarization wave action potential (nerve impulse) • Polarity across membrane is momentarily reversed • K+ channels also open but more slowly allowing repolarization

6. 5. U 4 An action potential consists of depolarization and repolarization of the

6. 5. U 4 An action potential consists of depolarization and repolarization of the neuron. • Repolarization – after action potential passes, membrane begins to repolarize • Na+ channels close and membrane becomes impermeable to Na+ • Open K+ channels allow K+ to leak out of the neuron repolarizing the membrane • Impulse is actually a series of depolarization and repolarization waves sweeping down the axon (takes place in less than 1 millisecond) • Then K+ channels close and sodium-potassium pumps are needed to reestablish resting conditions • For every three sodium ions pumped out, two potassium ions are pumped in Impulse conduction video

6. 5. U 6 Propagation of nerve impulses is the result of local currents

6. 5. U 6 Propagation of nerve impulses is the result of local currents that cause each successive part of the axon to reach the threshold potential. Propagation of a nerve impulse in un-myelinated axons Cell body http: //cnx. org/resources/0 d 4 d 8 e 978090 c 5 adf 07 cc 1661372 b 69 be 3496 ec 6/Figure_35_02_04. png

6. 5. U 6 Propagation of nerve impulses is the result of local currents

6. 5. U 6 Propagation of nerve impulses is the result of local currents that cause each successive part of the axon to reach the threshold potential. Propagation of a nerve impulse in un-myelinated axons http: //highered. mheducation. com/olc/dl/120107/bio_d. swf

6. 5. S 1 Analysis of oscilloscope traces showing resting potentials and action potentials.

6. 5. S 1 Analysis of oscilloscope traces showing resting potentials and action potentials. Na+/K+ pump Na+ & K+ channels closed Na+ channels open Inside of cell becomes positive Na+ channels close K+ channels open Negative charge restored inside Na+/K+ pump Na+ & K+ channels closed

6. 5. U 2 The myelination of nerve fibers allows for saltatory conduction. •

6. 5. U 2 The myelination of nerve fibers allows for saltatory conduction. • Myelinated vs. Non-myelinated • Impulse conduction is slower in unmyelinated axons • Here there is continuous conduction, the entire axon must depolarize • Vertebrate neurons are myelinated – speeds up transmission • Depolarization occurs only at the Nodes of Ranvier – Action Potential “jumps” from one node to the next Saltatory conduction (“to leap”) • Degradation of the impulse is reduced and allows the impulse to travel longer distances • Energy expenditure is reduced as the quantity of sodium and potassium ions that need to be pumped to restore resting potential is less than that of a unmyelintated axon *The jump along the axon is actually just • Diameter of axon also affects speed of transmission the very rapid conduction inside the myelinated portion of the axon. • Larger diameters transmit faster Myelinated vs. non-myelinated animation: http: //www. wiley. com/college/jenkins/0470227583/animations/ch 12/nerve 3 a/screen_3_2. swf

6. 5. U 7 Synapses are junctions between neurons and receptor or effector cells.

6. 5. U 7 Synapses are junctions between neurons and receptor or effector cells. • Synapse (synaptic cleft or gap) – gap between axon of one neuron and dendrites of the next or between a neuron and an effector • Synapse between neuron and muscle cell is called a neuromuscular junction or motor end plate

6. 5. U 8 When presynaptic neurons are depolarized they release a neurotransmitter into

6. 5. U 8 When presynaptic neurons are depolarized they release a neurotransmitter into the synapse. AND 6. 5. U 9 A nerve impulse is only initiated if the threshold potential is reached.

6. 5. U 8 When presynaptic neurons are depolarized they release a neurotransmitter into

6. 5. U 8 When presynaptic neurons are depolarized they release a neurotransmitter into the synapse. AND 6. 5. U 9 A nerve impulse is only initiated if the threshold potential is reached.

6. 5. A 1 Secretion and reabsorption of acetylcholine by neurons at synapses. Acetylcholine

6. 5. A 1 Secretion and reabsorption of acetylcholine by neurons at synapses. Acetylcholine is a neurotransmitter used in many synapses through the nervous system One use is at the neuromuscular junction, i. e. it is the molecule that motor neurons release to activate muscles. Interfering with the action of acetylcholine can cause a range of effect from paralysis to convulsions. http: //faculty. pasadena. edu/dkwon/chap%208_files/image 61. png

6. 5. A 2 Blocking of synaptic transmission at cholinergic synapses in insects by

6. 5. A 2 Blocking of synaptic transmission at cholinergic synapses in insects by binding of neonicotinoid pesticides to acetylcholine receptors.

6. 5. A 2 Blocking of synaptic transmission at cholinergic synapses in insects by

6. 5. A 2 Blocking of synaptic transmission at cholinergic synapses in insects by binding of neonicotinoid pesticides to acetylcholine receptors.

6. 5. A 2 Blocking of synaptic transmission at cholinergic synapses in insects by

6. 5. A 2 Blocking of synaptic transmission at cholinergic synapses in insects by binding of neonicotinoid pesticides to acetylcholine receptors.

Nature of science: Cooperation and collaboration between groups of scientists - biologists are contributing

Nature of science: Cooperation and collaboration between groups of scientists - biologists are contributing to research into memory and learning. (4. 3) Nowadays scientists often work in multidisciplinary teams for example the Centre for Neural Circuits and Behaviour (CNCB) The aim of the CNCB is to understand how intelligence emerges from the physical interaction of nerve cells. Studying the brain from this top-down approach to answer such fundamental questions requires techniques and understanding from a range of disciplines. Gero Miesenböck FRS Waynflete Professor of Physiology, Wellcome Investigator Stephen Goodwin Professor of Neurogenetics, Wellcome Investigator Martin Booth Professor of Engineering Science Tim Vogels Sir Henry Dale Fellow (physicsist) Korneel Hens Group Leader (Biochemist) Scott Waddell Professor of Neurobiology, Wellcome Trust Senior Research Fellow in Basic Biomedical Sciences http: //www. cncb. ox. ac