2142009 1 Pegaptanib Sodium MACUGEN for Macular Edema

21/4/2009 1

Pegaptanib Sodium (MACUGEN) for Macular Edema Secondary to Central Retinal Vein Occlusion Mahmood J Showail

Central retinal vein occlusion (CRVO) �CRVO is a common retinal vascular disorder. �Clinically, CRVO presents with variable visual loss; � the fundus may show retinal hemorrhages, dilated tortuous retinal veins, cotton-wool spots, macular edema, and optic disc edema

classifications �Broadly, CRVO can be divided into 2 clinical types, ischemic and nonischemic �Non-ischemic CRVO is the milder form of the disease � It may present with good vision, few retinal hemorrhages and cotton-wool spots � no RAPD and good perfusion to the retina. � It may resolve fully with good visual outcome or may progress to the ischemic type.

�Ischemic CRVO is the severe form of the disease. � ischemic CRVO presents with severe visual loss, extensive retinal hemorrhages and cotton-wool spots, � presence of RAPD, poor perfusion to retina, � presence of severe electroretinographic changes. � patients may end up with neovascular glaucoma and a painful blind eye

Pathophysiology � The exact pathogenesis of the thrombotic occlusion of the central retinal vein is not known. � Thrombotic occlusion of the central retinal vein can occur as a result of various pathologic insults, including � compression of the vein (mechanical pressure due to structural changes in lamina cribrosa, � eg, glaucomatous cupping, inflammatory swelling in optic nerve, orbital disorders); � vessel wall changes (eg, vasculitis); � changes in the blood (eg, deficiency of thrombolytic factors, increase in clotting factors).

CRVO leads to the backup of the blood in the retinal venous system and ↑↑ resistance to venous blood flow. This increased resistance causes stagnation of the blood and ischemic damage to the retina. The ischemic damage to the retina stimulates ↑↑ production of vascular endothelial growth factor (VEGF) in the vitreous cavity. ↑↑VEGF stimulate neovascularization of the posterior and anterior segment (responsible for secondary complications due to CRVO) Also, VEGF causes capillary leakage leading to macular edema (which is the leading cause of visual loss in CRVO)

� Macular edema following central retinal vein occlusion (CRVO) is the major cause of vision loss. � No United States Food and Drug Administration–approved pharmacologic treatments exist for macular edema in the setting of CRVO. 1 � Grid photocoagulation does not improve visual acuity when compared with controls 2 1. Central Vein Occlusion Study Group. A randomized clinical trial of early panretinal photocoagulation for ischemic central vein occlusion: the Central Vein Occlusion Study Group N report. Ophthalmology. 1995; 102(10): 1434 -1444. 2. Central Vein Occlusion Study Group. Evaluation of grid pattern photocoagulation for macular edema in central vein occlusion: the Central Vein Occlusion Study Group M report. Ophthalmology. 1995; 102(10): 1425 -1433.

MACUGEN® (pegaptanib sodium injection) � Pegaptanib, a 40 -k. Da RNA aptamer, binds to VEGF 165, the predominant pathological isoform in ischemia mediated ocular neovascularization and in diseases such as diabetic macular edema. � Pegaptanib sodium is represented by the following structural formula: � and n is approximately 450.

MACUGEN® Mechanism of Action �Pegaptanib is a selective vascular endothelial growth factor (VEGF) antagonist. �VEGF is a secreted protein that selectively binds and activates its receptors located primarily on the surface of vascular endothelial cells. � VEGF induces angiogenesis, and increases vascular permeability and inflammation, all of which are thought to contribute to the progression of the neovascularization.

�Clinical trials have suggested that intravitreous injection of pegaptanib sodium can be effective in the treatment of � diabetic macular edema (1) � proliferative diabetic retinopathy(2) � neovascular age-related macular degeneration (3) 1. Ng EW, Shima DT, Calias P, Cunningham ET Jr, Guyer DR, Adamis AP. Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat Rev Drug Discov. 2006; 5(2): 123132. 2. Cunningham ET Jr, Adamis AP, Altaweel M, et al; Macugen Diabetic Retinopathy Study Group. A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema. Ophthalmology. 2005; 112(10): 1747 -1757. 3. Adamis AP, Altaweel M, Bressler NM, et al; Macugen Diabetic Retinopathy Study Group. Changes in retinal neovascularization after pegaptanib (Macugen) therapy in diabetic individuals. Ophthalmology. 2006; 113(1): 23 -28.

So, does it work for macular edema due to CRVO? !

egaptanib Sodium for Macular Edema Secondary to Central Retinal Vein Occlusio John J. Wroblewski, MD; John A. Wells III, MD; Anthony P. Adamis, MD; Ronald R. Buggage, MD; Emmett T. Cunningham Jr, MD, Ph. D; Mauro Goldbaum, MD; David R. Guyer, MD; Barrett Katz, MD, MBA; Michael M. Altaweel, MD; for the Pegaptanib in Central Retinal Vein Occlusion Study Group Arch Ophthalmol. 2009; 127(4): 374 -380

Objectives To assess the safety and efficacy of intravitreous pegaptanib sodium for the treatment of macular edema following central retinal vein occlusion (CRVO).

Methods �This was a randomized, dose-ranging, double masked, sham-controlled clinical trial. �The study was conducted between August 2004 and September 2006. �It was conducted within multiple centers all over the world ( Australia, France, Germany, Israel, Spain, and the United States).

�It includes patients with CRVO for 6 months or less duration who will receive pegaptanib sodium or sham injection every 6 weeks for 24 weeks. �A total of 98 patients entered the study, with 33 patients in both the 0. 3 -mg and 1 -mg pegaptanib sodium groups and 32 in the sham group. � Main Outcome Measure: Visual acuity at week 30

�Eligible patients were allocated equally (1: 1: 1) to 1 of 3 treatment arms 0. 3 mg of pegaptanib sodium Sham injectons 1 mg of pegaptanib sodium At baseline, subject characteristics were comparable and visual acuity was well balanced across study arms

Results �Patients treated with pegaptanib sodium were less likely to lose 15 or more letters � 9% and 0. 3 -mg pegaptanib sodium group ( P=. 03 ) � 6% 1 -mg pegaptanib sodium groups (P=. 01) � 31% sham-treated eyes

Figure 2. Distributions of changes in visual acuity from baseline at 6 and 30 weeks.

Patients treated with pegaptanib sodium showed greater improvement in mean visual acuity • 7. 1 letters 0. 3 -mg pegaptanib sodium group ( P=. 09 ) • 9. 9 letters , 1 -mg pegaptanib sodium groups (P=. 02) • − 3. 2 letters with sham

Cont. Results �By week 1, the mean central retinal thickness decreased by � 269 μm in 0. 3 -mg group (P=. 001). � 210 μm in 1 -mg pegaptanib sodium groups � 5 μm with sham Figure 3. Mean change from baseline in center point thickness. Last observation carried forward. *P. 001.

Conclusions: �Based on this 30 -week study, intravitreous pegaptanib sodium appears to provide visual and anatomical benefits in the treatment of macular edema following CRVO. �Improvement with intravitreous pegaptanib sodium treatment of macular edema following CRVO suggest a role for vascular endothelial growth factor in the pathogenesis of this condition.

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