171129 case 3 1 Brain Sulcus gyrus temporal

171129 case 발표 - 3조 사진 1: Brain 환자 Sulcus ↑ gyrus ↓ -> temporal lobe atrophy 정상 뇌

171129 case 발표 - 3조 사진 2: Brain 단면 환자 Wider ventricles, hippocampus atrophy 정상 뇌

171129 case 발표 - 3조 사진 3: 현미경 소견 환자 Neurofibrillary tangles : neuronal intracytoplasmic inclusions hyperphosphorylation of a microtubule-associated protein tau, aggregated in an insoluble form

171129 case 발표 - 3조 사진 4: Thioflavin staining Amyloid 침착 확인

171129 case 발표 - 3조 사진 5: EM 화살표 – Prominent nuclear pores * : Paired helical filaments in neurofibrillary tangle-bearing neuron

171129 case 발표 - 3조 • Brain atrophy (temporal lobe) • Enlarged ventricles, hippocampus atrophy • Neurofibrillary tangles • Amyloid deposition ∴ Final diagnosis – Alzheimer’s Disease

171129 case 발표 - 3조 Sources https: //library. med. utah. edu/Web. Path/CNSHTML/CNS 098. html http: //thebrain. mcgill. ca/flash/d/d_08_cl/d_08_cl_alz. html http: //www. downstate. edu/pathology/Dr. Suzanne. S. Mirra. MD. html - Robbins and Cotran Pathologic Basis of Disease 9 e