1 Tissues of of the Immune Response Hugh

1 Tissues of of the Immune Response Hugh B. Fackrell Filename: tissuesv 7 11/04/26

2 Structure and Function of of the Lymphatic System Lymphatic system Primary Lymphoid tissues Secondary Lymphoid Tissues Next 11/04/26

3 Lymphatic System: Function Generate lymphocytes committed to a particular antigenic specificity Create an environment to trap antigens from various tissues, spaces or fluids Provide sites where the committed lymphocytes interact with the trapped antigens Next 11/04/26

4 Committed Lymphocytes Immature lymphocytes Lymphocytes mature in the primary lymphoid organs generated by hematopoiesis of pleuripotent stem cells within the bone marrow. Bone Marrow, Thymus, Bursa (in birds) Mature lymphocytes migrate to the secondary lymphoid organs Lymph nodes, spleen, mucosal associated lymphoid tissues 11/04/26

5 Primary Lymphoid Tissues B cells Birds Bursa of Fabricius Mammals Fetal Liver Bone Marrow T Cells Thymus 11/04/26

6 Bursa Location Structure Function 11/04/26

7 Avian Lymphoid System 11/04/26

8 Bursa of of Fabricius: Follicles 11/04/26

9 Bursa of of Fabricius: X-Section 11/04/26

10 Bursa: B B cell germinal centers 11/04/26

11 B B cell Origins Hemopoietic stem cells develop in the fetal liver Later they are produced in the Bone Marrow “Bursal equivalent” Next 11/04/26

12 Fetal liver: Hematopoiesis 11/04/26

13 Bone Marrow Scanning EM EM 11/04/26

14 Bone Marrow Differentiation 11/04/26

15 Thymus Location Structure Circulation Function Summary Diagram 11/04/26

16 Thymus: Location 11/04/26

17 Thymus: Lobules 11/04/26

18 Thymus: X X section 11/04/26

19 Thymus: Development 11/04/26

20 Thymus: Embrogenisis 11/04/26

21 Thymus: Summary Diagram 11/04/26

22 Athymic Mouse “Nude” mouse - lacks hair follicles Lacks developed thymus few circulating T cells No cell mediated immunity 11/04/26

23 “Nude Mouse” 11/04/26

24 Lymph Nodes Distribution Structure Circulation Function Summary Diagram 11/04/26

25 Lymphatic System 11/04/26

26 Node: Circulation 11/04/26

27 Node: TD TD & & TI TI areas 11/04/26

28 Node: X X section Capsule Cortex Paracortex Medulla 11/04/26

29 Node: Diagram 22 11/04/26

30 Cortex 11/04/26

31 Node: Diagram Primary Follicle Efferent lymphatic Afferent lymphatic 11/04/26

32 Node: B B cells in in cortex 11/04/26

33 Node: Germinal Center 11/04/26

34 Node: Reticular network 11/04/26

35 Node Follicle: Mantle of of lymphocytes 11/04/26

36 Paracortex 11/04/26

37 Node TT Cells Diffuse cortex 11/04/26

38 Node: TT Cells in in Paracortex 11/04/26

39 Node: TT cell depletion 11/04/26

40 Medulla Thymic Dependent area T cells localize 11/04/26

41 Lymph Node: Medulla 11/04/26

42 Node: LM LM Medulla 11/04/26

43 Node: Medullary Sinus 11/04/26

44 Node: Subcapsular Sinus 11/04/26

45 Node: EM EM of of Medulla 11/04/26

46 Node: Primary Follicle 11/04/26

47 Node: Diffuse Cortex 11/04/26

48 Node: HEV 11/04/26

49 Node: Diagram summary 11/04/26

50 Spleen Location Structure Circulation Immunological function Summary Diagram 11/04/26

51 Spleen: Connective Tissue 11/04/26

52 Spleen: X X section low mag 11/04/26

53 Spleen : : X X section higher mag 11/04/26

54 Spleen: circulation 11/04/26

55 Spleen EM: Marginal zone 11/04/26

56 Marginal zone B B cells 11/04/26

57 Antigen localization in in Spleen 11/04/26

58 Spleen: Summary Diagram 11/04/26

59 The End 11/04/26