1 Corneal Dystrophies How many categories of corneal
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1 Corneal Dystrophies How many categories of corneal dystrophies are listed in the Cornea book?
2 Corneal Dystrophies How many categories of corneal dystrophies are listed in the Cornea book? Four
3 Corneal Dystrophies ? ? What are the four categories of corneal dystrophies? ? ?
4 Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies What are the four categories of corneal dystrophies? Stromal Dystrophies Endothelial Dystrophies
5 Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies What are the four categories of corneal dystrophies? Stromal Dystrophies Flip back and forth between those first two slides until you have all four categories on lock! Endothelial Dystrophies
6 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) ? 2) ? 3) ? 4) ? 5) ? 6) ? Epithelial-Stromal TGFBI Dystrophies Stromal Dystrophies Endothelial Dystrophies What are the six epithelial/subepithelial corneal dystrophies?
7 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies Stromal Dystrophies Endothelial Dystrophies What are the six epithelial/subepithelial corneal dystrophies?
8 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies Stromal Dystrophies Endothelial Dystrophies The Cornea book pays these no mind, so you shouldn’t either
9 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies Stromal Dystrophies Endothelial Dystrophies But make sure you know these four! They’re blanked out on the next slide so you can flip back and forth between that one and this one until you’ve got ‘em
10 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) ? 2) ? 3) ? 4) ? 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies Stromal Dystrophies Endothelial Dystrophies But make sure you know these four! They’re blanked out on the next slide so you can flip back and forth between that one and this one until you’ve got ‘em
11 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies What does TGFBI stand for in this context? Stromal Dystrophies Endothelial Dystrophies
12 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies What does TGFBI stand for in this context? ‘Transforming growth factor beta induced. ’ It refers to the gene that codes for the (faulty) protein responsible for the dystrophy. Stromal Dystrophies Endothelial Dystrophies
13 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies What does TGFBI stand for in this context? ‘Transforming growth factor beta induced. ’ It refers to the gene that codes for the (faulty) protein responsible for the dystrophy. What is the name of the protein involved in the TGFBI dystrophies? Keratoepithelin (the Cornea book refers in passing to the TGFBI Stromal Dystrophies conditions as keratoepithelin dystrophies) What is the clinical hallmark of the keratoepithelin dystrophies? Recurrent epithelial erosions Endothelial Dystrophies
14 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies What does TGFBI stand for in this context? ‘Transforming growth factor beta induced. ’ It refers to the gene that codes for the (faulty) protein responsible for the dystrophy. What is the name of the protein involved in the TGFBI dystrophies? Keratoepithelin (the Cornea book refers in passing to the TGFBI Stromal Dystrophies conditions as keratoepithelin dystrophies) What is the clinical hallmark of the keratoepithelin dystrophies? Recurrent epithelial erosions Endothelial Dystrophies
15 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies What does TGFBI stand for in this context? ‘Transforming growth factor beta induced. ’ It refers to the gene that codes for the (faulty) protein responsible for the dystrophy. What is the name of the protein involved in the TGFBI dystrophies? Keratoepithelin (the Cornea book refers in passing to the TGFBI Stromal Dystrophies conditions as keratoepithelin dystrophies) What is the clinical hallmark of the keratoepithelin dystrophies? Recurrent epithelial erosions Endothelial Dystrophies
16 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies What does TGFBI stand for in this context? ‘Transforming growth factor beta induced. ’ It refers to the gene that codes for the (faulty) protein responsible for the dystrophy. What is the name of the protein involved in the TGFBI dystrophies? Keratoepithelin (the Cornea book refers in passing to the TGFBI Stromal Dystrophies conditions as keratoepithelin dystrophies) What is the clinical hallmark of the keratoepithelin dystrophies? Recurrent epithelial erosions Endothelial Dystrophies
17 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies What does TGFBI stand for in this context? ‘Transforming growth factor beta induced. ’ It refers to the gene that codes for the (faulty) protein responsible for the dystrophy. What is the name of the protein involved in the TGFBI dystrophies? Keratoepithelin (the Cornea book refers in passing to the TGFBI Stromal Dystrophies conditions as keratoepithelin dystrophies) What is the clinical hallmark of the keratoepithelin dystrophies? Recurrent epithelial erosions The Cornea book considered this factoid important enough to make it one of three ‘Highlights’ for the Dystrophy chapter—take note of it! Endothelial Dystrophies
18 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) ? 2) ? 3) ? 4) ? 5) ? 6) ? Stromal Dystrophies Endothelial Dystrophies What are the six epithelial -stromal TGFBI corneal dystrophies?
19 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies Endothelial Dystrophies What are the six epithelial -stromal TGFBI corneal dystrophies?
20 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy How do you pronounce this? RICE BOO-kler Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) How do you pronounce this? 5) Granular type 1 TEAL BEN-key 6) Granular type 2 Stromal Dystrophies Endothelial Dystrophies
21 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy How do you pronounce this? RICE BOO-kler Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) How do you pronounce this? 5) Granular type 1 TEAL BEN-key 6) Granular type 2 Stromal Dystrophies Endothelial Dystrophies
22 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, hallmark variant types (III, IIIA, I/IIIA, and IV) Thiel-Behnke? What is the histologic of Reis-Bückler 5) Granular type 1 Disruption/fragmentation of Bowman’s layer 6) Granular type 2 Stromal Dystrophies Endothelial Dystrophies
23 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, hallmark variant types (III, IIIA, I/IIIA, and IV) Thiel-Behnke? What is the histologic of Reis-Bückler 5) Granular type 1 Disruption/fragmentation of Bowman’s layer 6) Granular type 2 Stromal Dystrophies Endothelial Dystrophies
24 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, hallmark variant types (III, IIIA, I/IIIA, and IV) Thiel-Behnke? What is the histologic of Reis-Bückler 5) Granular typeof 1 Bowman’s layer Disruption/fragmentation 6) Granular type 2 Stromal Dystrophies The corneal-dystrophy section of the Cornea book underwent a major revision recently. In what ‘category of corneal dystrophy’ were Reis-Bückler and Thiel-Behnke in previous editions? The ’Corneal Dystrophies of Bowmans’ Endothelial Dystrophies
25 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, hallmark variant types (III, IIIA, I/IIIA, and IV) Thiel-Behnke? What is the histologic of Reis-Bückler 5) Granular typeof 1 Bowman’s layer Disruption/fragmentation 6) Granular type 2 Stromal Dystrophies The corneal-dystrophy section of the Cornea book underwent a major revision recently. In what ‘category of corneal dystrophy’ were Reis-Bückler and Thiel-Behnke in previous editions? The ’Corneal Dystrophies of Bowman’s’ Endothelial Dystrophies
26 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy These two primarily involve 2) Thiel-Behnke corneal dystrophy Bowman’s membrane 3) Lattice, type 1 There are two ‘lattice’ sets 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 Two are ‘granular’ forms 6) Granular type 2 Stromal Dystrophies As a way to help remember them, think of the TGFBI dystrophies as consisting of three pairs of conditions: Two Bowman’s dystrophies, two lattice dystrophies, and two granular dystrophies Endothelial Dystrophies
27 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 Remembering the two granular types 6) Granular type 2 is easy—there’s a type 1, and a type 2 Stromal Dystrophies Endothelial Dystrophies
28 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies Endothelial Dystrophies For lattice, there’s type 1, and type ‘everything else’ (which weirdly does not include a type 2)
29 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) ? 2) ? 3) ? 4) ? 5) ? 6) ? Endothelial Dystrophies What are the six non-TGFBI stromal dystrophies?
30 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies What are the six non-TGFBI stromal dystrophies?
31 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies The Cornea book addresses all six of these, 1) Macular corneal dystrophy but Macular is covered in greatest detail 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies
32 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies Note that, conveniently, there are six conditions in these categories (this will help you remember how many names you have to come up with for each)
33 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies 1) ? 2) ? 3) ? What are three endothelial dystrophies?
34 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy What are three endothelial dystrophies?
35 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies All three of these are important, albeit for different reasons. Being both 1) Macular corneal dystrophy common and devastating, Fuchs gets the most coverage in the Cornea book. 2) Schnyder corneal dystrophy PPMD gets a fair amount of ink as well. CHED gets less attention, but is 3) Congenital stromal corneal dystrophy important for another reason: It is on the DDx for infantile cloudy cornea (it’s 4) Fleck corneal dystrophy the E in 5)the infamous STUMPED Posterior amorphous cornealmnemonic). dystrophy See slide-set K 9 for further info on this 6) important topic. corneal dystrophy Pre-Descemet Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy
36 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies All three of these are important, albeit for different reasons. Being both 1) Macular corneal dystrophy common and devastating, Fuchs gets the most coverage in the Cornea book. 2) Schnyder corneal dystrophy PPMD gets a fair amount of ink as well. CHED gets less attention, but is 3) Congenital stromal corneal dystrophy important for another reason: It is on the DDx for infantile cloudy cornea (it’s 4) Fleck corneal dystrophy the E in 5)the infamous STUMPED Posterior amorphous cornealmnemonic). dystrophy See slide-set K 9 for further info on this 6) important topic. corneal dystrophy Pre-Descemet Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy
37 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies All three of these are important, albeit for different reasons. Being both 1) Macular corneal dystrophy common and devastating, Fuchs gets the most coverage in the Cornea book. 2) Schnyder corneal dystrophy PPMD gets a fair amount of ink as well. CHED gets less attention, but is 3) Congenital stromal corneal dystrophy important for another reason: It is on the DDx for infantile cloudy cornea (it’s 4) Fleck corneal dystrophy the E in 5)the infamous STUMPED Posterior amorphous cornealmnemonic). dystrophy See slide-set K 9 for further info on this 6) important topic. corneal dystrophy Pre-Descemet Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy
38 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies All three of these are important, albeit for different reasons. Being both 1) Macular corneal dystrophy common and devastating, Fuchs gets the most coverage in the Cornea book. 2) Schnyder corneal dystrophy PPMD gets a fair amount of ink as well. CHED gets less attention, but is 3) Congenital stromal corneal dystrophy important for another reason: It is on the DDx for infantile cloudy cornea (it’s 4) Fleck corneal dystrophy the E in 5)the infamous STUMPED Posterior amorphous cornealmnemonic). dystrophy See slide-set K 9 for further info on this 6) important topic. corneal dystrophy Pre-Descemet Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy
39 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy Which is/are inherited AR?
40 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy--AR 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Which is/are inherited AR? Stromal Dystrophies 1) Macular corneal dystrophy--AR 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy--AR
41 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy--AR 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 Which 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy--AR 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy--AR is/are inherited X-dominant?
42 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy--X-linked dominant 4) Gelatinous droplike corneal dystrophy--AR 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 Which 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy--AR 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy--AR is/are inherited X-dominant?
43 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy--X-linked dominant 4) Gelatinous droplike corneal dystrophy--AR 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 For which is the inheritance as yet unestablished? Stromal Dystrophies 1) Macular corneal dystrophy--AR 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy--AR
44 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy--unestablished 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy--X-linked dominant 4) Gelatinous droplike corneal dystrophy--AR 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 For which is the inheritance as yet unestablished? Stromal Dystrophies 1) Macular corneal dystrophy--AR 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy--unestablished Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy--unestablished 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy--AR
45 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy--unestablished 2) Meesmann epithelial corneal dystrophy--AD 3) Lisch epithelial corneal dystrophy--X-linked dominant 4) Gelatinous droplike corneal dystrophy--AR 5) Epithelial recurrent erosion dystrophies--AD 6) Subepithelial mucinous corneal dystrophy--AD Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy--AD 2) Thiel-Behnke corneal dystrophy--AD 3) Lattice, type 1 --AD 4) Lattice, variant types (III, IIIA, I/IIIA, IV)--AD 5) Granular type 1 --AD 6) Granular type 2 --AD Takeaway: The most common inheritance pattern is AD Stromal Dystrophies 1) Macular corneal dystrophy--AR 2) Schnyder corneal dystrophy--AD 3) Congenital stromal corneal dystrophy--AD 4) Fleck corneal dystrophy--AD 5) Posterior amorphous corneal dystrophy -AD 6) Pre-Descemet corneal dystrophy--unestablished Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy--unestablished 2) Posterior polymorphous corneal dystrophy--AD 3) Congenital hereditary endothelial dystrophy--AR
46 Corneal Dystrophies OK, review time. If you can’t answer every question correctly, you need to spend more time with the slide-set. Get these basics down before tackling the other dystrophy-related slide-sets!
47 Corneal Dystrophies ? ? What are the four categories of corneal dystrophies? ? ?
48 Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies What are the four categories of corneal dystrophies? Stromal Dystrophies Endothelial Dystrophies
49 Corneal Dystrophies Epithelial and Subepithelial Dystrophies ? Epithelial-Stromal TGFBI Dystrophies ? Stromal Dystrophies ? Endothelial Dystrophies ? How many conditions are in each category?
50 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) 2) 3) 4) 5) 6) ? Epithelial-Stromal TGFBI Dystrophies 1) 2) 3) 4) 5) 6) ? Stromal Dystrophies 1) 2) 3) 4) 5) 6) ? Endothelial Dystrophies 1) 2) 3) ? How many conditions are in each category?
51 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) ? 2) ? 3) ? 4) ? 5) 6) Epithelial-Stromal TGFBI Dystrophies 1) 2) 3) 4) 5) 6) Stromal Dystrophies 1) 2) 3) 4) 5) 6) Endothelial Dystrophies 1) 2) 3) What are the four epithelial/subepithelial corneal dystrophies that must be learned?
52 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) 2) 3) 4) 5) 6) Stromal Dystrophies 1) 2) 3) 4) 5) 6) Endothelial Dystrophies 1) 2) 3) What are the four epithelial/subepithelial corneal dystrophies that must be learned?
53 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies 1) 2) 3) The Epithelial-Stromal TGFBI dystrophies are also known as the… 4) 5) 6) Stromal Dystrophies 1) 2) 3) 4) 5) 6) Endothelial Dystrophies 1) 2) 3)
54 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies 1) 2) 3) The Epithelial-Stromal TGFBI dystrophies are also known as the… 4) keratoepithelin dystrophies, named after the (defective) protein 5) coded for by the TGFBI gene. 6) Stromal Dystrophies 1) 2) 3) 4) 5) 6) Endothelial Dystrophies 1) 2) 3)
55 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, notorious for causing… 1) 2) 3) The Epithelial-Stromal TGFBI dystrophies are also known as the… 4) keratoepithelin dystrophies, named after the (defective) protein 5) coded for by the TGFBI gene. They are notorious for causing… 6) Stromal Dystrophies 1) 2) 3) 4) 5) 6) Endothelial Dystrophies 1) 2) 3)
56 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, notorious for causing…REEs 1) 2) 3) The Epithelial-Stromal TGFBI dystrophies are also known as the… 4) keratoepithelin dystrophies, named after the (defective) protein 5) coded for by the TGFBI gene. They are notorious for causing… 6) recurrent epithelial erosions (REE). Stromal Dystrophies 1) 2) 3) 4) 5) 6) Endothelial Dystrophies 1) 2) 3)
57 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, notorious for causing…REEs 1) two words Two primarily involve Bowman’s membrane 2) 3) There are two ‘lattice’ sets 4) 5) Two are ‘granular’ forms 6) Stromal Dystrophies 1) 2) 3) 4) 5) 6) Endothelial Dystrophies 1) 2) 3) The TGFBI dystrophies can be grouped into three pairs of conditions. What is the common element for each pair?
58 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, notorious for causing…REEs 1) Two primarily involve Bowman’s membrane 2) 3) There are two ‘lattice’ sets 4) 5) Two are ‘granular’ forms 6) Stromal Dystrophies 1) 2) 3) 4) 5) 6) Endothelial Dystrophies 1) 2) 3) The TGFBI dystrophies can be grouped into three pairs of conditions. What is the common element for each pair?
59 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, notorious for causing…REEs 1) ? Two primarily involve Bowman’s membrane 2) ? 3) There are two ‘lattice’ sets What 4)are the two that primarily involve Bowman’s? 5) Two are ‘granular’ forms 6) Stromal Dystrophies 1) 2) 3) 4) 5) 6) Endothelial Dystrophies 1) 2) 3)
60 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, notorious for causing…REEs 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy Two primarily involve Bowman’s membrane 3) There are two ‘lattice’ sets What 4)are the two that primarily involve Bowman’s? 5) Two are ‘granular’ forms 6) Stromal Dystrophies 1) 2) 3) 4) 5) 6) Endothelial Dystrophies 1) 2) 3)
61 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, notorious for causing…REEs 1) Reis-Bücklers corneal dystrophy Two primarily involve Bowman’s membrane 2) Thiel-Behnke corneal dystrophy 3) ? There are two ‘lattice’ sets 4) ? 5) Two are ‘granular’ forms What 6)are the two Lattice sets? Stromal Dystrophies 1) 2) 3) 4) 5) 6) Endothelial Dystrophies 1) 2) 3)
62 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, notorious for causing…REEs 1) Reis-Bücklers corneal dystrophy Two primarily involve Bowman’s membrane 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 There are two ‘lattice’ sets 4) Lattice, type everything else 5) Two are ‘granular’ forms What 6)are the two Lattice sets? Stromal Dystrophies 1) 2) 3) 4) 5) 6) Endothelial Dystrophies 1) 2) 3)
63 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, notorious for causing…REEs 1) Reis-Bücklers corneal dystrophy Two primarily involve Bowman’s membrane 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 There are two ‘lattice’ sets 4) Lattice, type everything else 5) ? Two are ‘granular’ forms 6) ? What are the two Granular forms? Stromal Dystrophies 1) 2) 3) 4) 5) 6) Endothelial Dystrophies 1) 2) 3)
64 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, notorious for causing…REEs 1) Reis-Bücklers corneal dystrophy Two primarily involve Bowman’s membrane 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 There are two ‘lattice’ sets 4) Lattice, type everything else 5) Granular type 1 Two are ‘granular’ forms 6) Granular type 2 What are the two Granular forms? Stromal Dystrophies 1) 2) 3) 4) 5) 6) Endothelial Dystrophies 1) 2) 3)
65 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, type everything else 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) ? 2) 3) 4) 5) 6) Endothelial Dystrophies 1) 2) 3) Which of the stromal dystrophies is ‘first among equals’ with respect to importance?
66 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, type everything else 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular 2) 3) 4) 5) 6) Endothelial Dystrophies 1) 2) 3) Which of the stromal dystrophies is ‘first among equals’ with respect to importance?
67 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, type everything else 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies 1) 2) 3) (Here’s the rest of the ‘stromal crew’)
68 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, type everything else 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies 1) ? 2) 3) This endothelial dystrophy is common and often devastating: This one is less common, less devastating: This one is quite uncommon, but is important because of its place on the STUMPED mnemonic for infantile cloudy cornea:
69 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, type everything else 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) 3) This endothelial dystrophy is common and often devastating: This one is less common, less devastating: This one is quite uncommon, but is important because of its place on the STUMPED mnemonic for infantile cloudy cornea:
70 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, type everything else 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) ? 3) This endothelial dystrophy is common and often devastating: This one is less common, less devastating: This one is quite uncommon, but is important because of its place on the STUMPED mnemonic for infantile cloudy cornea:
71 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, type everything else 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy This endothelial dystrophy is common and often devastating: This one is less common, less devastating: This one is quite uncommon, but is important because of its place on the STUMPED mnemonic for infantile cloudy cornea: Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3)
72 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, type everything else 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) ? This endothelial dystrophy is common and often devastating: This one is less common, less devastating: This one is quite uncommon, but is important because of its place on the STUMPED mnemonic for infantile cloudy cornea:
73 Corneal Dystrophies Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, type everything else 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy This endothelial dystrophy is common and often devastating: This one is less common, less devastating: This one is quite uncommon, but is important because of its place on the STUMPED mnemonic for infantile cloudy cornea: Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy
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