1 Confidential For Internal Use Only Asthma DUPIXENT

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< 1 Confidential- For Internal Use Only

Asthma DUPIXENT is indicated as an add-on maintenance treatment in patients with moderate-to-severe asthma

Asthma DUPIXENT is indicated as an add-on maintenance treatment in patients with moderate-to-severe asthma aged 12 years and older with an eosinophilic phenotype or with oral corticosteroid dependent asthma. Limitation of Use: DUPIXENT is not indicated for the relief of acute bronchospasm or status asthmaticus. Chronic Rhinosinusitis with Nasal Polyposis DUPIXENT 300 mg is indicated as an add-on maintenance treatment in adult patients with inadequately controlled chronic rhinosinusitis with nasal polyposis (CRSw. NP). Atopic Dermatitis DUPIXENT is indicated for the treatment of patients aged 12 years and older with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. DUPIXENT can be used with or without topical corticosteroids. 2 Confidential- כפי For לרופא Internal. עודכן על פי הנחיות משרד הבריאות / שאושר בעלון Use לעיין Only *למידע מלא יש <

Dupixent addresses Type 2 Inflammation In Appropriate Patients With Asthma 2, 3 < 3

Dupixent addresses Type 2 Inflammation In Appropriate Patients With Asthma 2, 3 < 3 Confidential- For Internal Use Only References: 1. Seys SF, Scheers H, Van den Brande P, et al. Cluster analysis of sputum cytokine-high profiles reveals diversity in T(h)2 -high asthma patients. Respir Res. 2017; 18(1): 39. doi: 10. 1186/s 12931 -017 -0524 -y 2. Peters MC, Mekonnen ZK, Yuan S, Bhakta NR, Woodruff PG, Fahy JV. Measures of gene expression in sputum cells can identify TH 2 -high and TH 2 -low subtypes of asthma. J Allergy Clin Immunol. 2014; 133(2): 388 -394. doi: 0. 1016/j. jaci. 2013. 07. 036 3. Tran TN, Zeiger RS, Peters SP, et al. Overlap of atopic, eosinophilic, and TH 2 -high asthma phenotypes in a general population with current asthma. Ann Allergy Asthma Immunol.

Dupixent is a human monoclonal antibody that specifically binds to a shared receptor complexes

Dupixent is a human monoclonal antibody that specifically binds to a shared receptor complexes for IL-4 & IL-13 2, 3 4 Confidential- For Internal Use Only . עודכן על פי הנחיות משרד הבריאות / *למידע מלא יש לעיין בעלון לרופא כפי שאושר <

* * * Secondary endpoint < 5 Confidential- For Internal Use Only

* * * Secondary endpoint < 5 Confidential- For Internal Use Only